Literature DB >> 23477294

A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate.

Kosuke Ohsawa1, Masahito Yoshida, Takayuki Doi.   

Abstract

A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 °C without losing the protecting groups on the phenolic hydroxyl group.

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Year:  2013        PMID： 23477294     DOI： 10.1021/jo400056k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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