Literature DB >> 23477247

[A new antiviral drug Triazavirin: results of phase II clinical trial].

O I Kiselev, E G Deeva, T I Mel'nikova, K N Kozeletskaia, A S Kiselev, V L Rusinov, V N Charushin, O N Chupakhin.   

Abstract

The results of the clinical trial testing the efficacy of a new anti-influenza drug Triazavirin are presented in this work. The data of the trial were gathered during the 2010 influenza season. The treatment with oral Triazavirin significantly reduced the duration of the main clinical symptoms of influenza (intoxication, fever, respiratory symptoms), decreased the incidence of the influenza-related complications and the use of symptomatic drugs. The re-isolation rate of the influenza A and B viruses was significantly lower in the patients who were using Triazavirin. The analysis of the clinical data showed that the optimal prescribed dosage was 250 mg 3 times a day.

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Year:  2012        PMID: 23477247

Source DB:  PubMed          Journal:  Vopr Virusol        ISSN: 0507-4088


  6 in total

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Authors:  Victor V Fedotov; Vladimir L Rusinov; Evgeny N Ulomsky; Evgeny M Mukhin; Evgeny B Gorbunov; Oleg N Chupakhin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-15       Impact factor: 1.490

2.  Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties.

Authors:  Tatyana S Shestakova; Sergey L Deev; Igor А Khalymbadzha; Vladimir L Rusinov; Alexander S Paramonov; Alexander S Arseniev; Zakhar O Shenkarev; Valery N Charushin; Oleg N Chupakhin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-12       Impact factor: 1.277

3.  Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent.

Authors:  Samar A El-Kalyoubi
Journal:  Chem Cent J       Date:  2018-05-23       Impact factor: 4.215

Review 4.  Clinical features and mechanistic insights into drug repurposing for combating COVID-19.

Authors:  Purva Asrani; Keshav Tiwari; Mathew Suji Eapen; Kielan Darcy McAlinden; Greg Haug; Matt D Johansen; Philip M Hansbro; Katie L Flanagan; Md Imtaiyaz Hassan; Sukhwinder Singh Sohal
Journal:  Int J Biochem Cell Biol       Date:  2021-11-05       Impact factor: 5.652

5.  Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems.

Authors:  V N Charushin; V L Rusinov; M V Varaksin; O N Chupakhin; O P Kovtun; A A Spasov
Journal:  Her Russ Acad Sci       Date:  2022-09-06       Impact factor: 0.552

6.  Aerosol Inhalation Delivery of Triazavirin in Mice: Outlooks for Advanced Therapy Against Novel Viral Infections.

Authors:  Sergey V Valiulin; Andrey A Onischuk; Sergey N Dubtsov; Anatoly M Baklanov; Sergey V An'kov; Maria E Plokhotnichenko; Tatyana G Tolstikova; Galina G Dultseva; Vladimir L Rusinov; Valery N Charushin; Vasily M Fomin
Journal:  J Pharm Sci       Date:  2020-11-26       Impact factor: 3.534

  6 in total

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