Ai-Hua Zuo1, Meng-Chun Cheng, Li Wang, Hong-Bin Xiao. 1. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China.
Abstract
OBJECTIVE: To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. METHOD: The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data. RESULT: After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide. CONCLUSION: The study is helpful for interpreting effective substance of Ligusticum chuanxiong.
OBJECTIVE: To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. METHOD: The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data. RESULT: After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide. CONCLUSION: The study is helpful for interpreting effective substance of Ligusticum chuanxiong.