BACKGROUND: Cancer of the cervix is the most common malignancy in women of childbearing age in Zambia. It is known to be associated with HIV infection and oncogenic strains of HPV. However, there are few studies of penile lesions as a predictor of malignant and premalignant cervical lesions in female partners. OBJECTIVES: The aim of the study was to determine the association between men with penile lesions and premalignant cervical lesions in their female partners. DESIGN: Thirty-seven couples were screened for penile and cervical lesions to determine the association between the two. The male partners had a biopsy and the female partners had a Pap smear. RESULTS: Among 37 female partners, 29 (78.3%) had some type of cervical lesion. Two (5.4%) were undetermined and 6 (16.3%) of the females had normal Pap smears. Among the spouses with diseased cervices 22 (59.4%) were premalignant and 5 (13.5%) were malignant. The combined prevalence of malignant or premalignant cervical lesions among female partners was 73.0%. The HIV prevalence in the cohort was 88.9% (among those who agreed to be tested). The prevalence of premalignant or malignant cervical lesions was 75% in HIV positive and HIV negative females, and 66.7% in those who refused HIV testing. CONCLUSION: This small pilot study suggests a high prevalence of premalignant or malignant lesions in females whose partners have penile lesions. In this cohort, HIV infection was not associated with a higher risk of neoplastic cervical lesions.
BACKGROUND:Cancer of the cervix is the most common malignancy in women of childbearing age in Zambia. It is known to be associated with HIV infection and oncogenic strains of HPV. However, there are few studies of penile lesions as a predictor of malignant and premalignant cervical lesions in female partners. OBJECTIVES: The aim of the study was to determine the association between men with penile lesions and premalignant cervical lesions in their female partners. DESIGN: Thirty-seven couples were screened for penile and cervical lesions to determine the association between the two. The male partners had a biopsy and the female partners had a Pap smear. RESULTS: Among 37 female partners, 29 (78.3%) had some type of cervical lesion. Two (5.4%) were undetermined and 6 (16.3%) of the females had normal Pap smears. Among the spouses with diseased cervices 22 (59.4%) were premalignant and 5 (13.5%) were malignant. The combined prevalence of malignant or premalignant cervical lesions among female partners was 73.0%. The HIV prevalence in the cohort was 88.9% (among those who agreed to be tested). The prevalence of premalignant or malignant cervical lesions was 75% in HIV positive and HIV negative females, and 66.7% in those who refused HIV testing. CONCLUSION: This small pilot study suggests a high prevalence of premalignant or malignant lesions in females whose partners have penile lesions. In this cohort, HIV infection was not associated with a higher risk of neoplastic cervical lesions.
Authors: Groesbeck P Parham; Vikrant V Sahasrabuddhe; Mulindi H Mwanahamuntu; Bryan E Shepherd; Michael L Hicks; Elizabeth M Stringer; Sten H Vermund Journal: Gynecol Oncol Date: 2006-07-27 Impact factor: 5.482
Authors: Stanley A Trask; Cynthia A Derdeyn; Ulgen Fideli; Yalu Chen; Sreelatha Meleth; Francis Kasolo; Rosemary Musonda; Eric Hunter; Feng Gao; Susan Allen; Beatrice H Hahn Journal: J Virol Date: 2002-01 Impact factor: 5.103
Authors: Xavier Castellsagué; F Xavier Bosch; Nubia Muñoz; Chris J L M Meijer; Keerti V Shah; Silvia de Sanjose; José Eluf-Neto; Corazon A Ngelangel; Saibua Chichareon; Jennifer S Smith; Rolando Herrero; Victor Moreno; Silvia Franceschi Journal: N Engl J Med Date: 2002-04-11 Impact factor: 91.245
Authors: Maaike C G Bleeker; Cornelis J A Hogewoning; Adriaan J C Van Den Brule; Feja J Voorhorst; Rick E Van Andel; Elle K J Risse; Theo M Starink; Chris J L M Meijer Journal: J Am Acad Dermatol Date: 2002-09 Impact factor: 11.527
Authors: V V Sahasrabuddhe; M H Mwanahamuntu; S H Vermund; W K Huh; M D Lyon; J S A Stringer; G P Parham Journal: Br J Cancer Date: 2007-04-17 Impact factor: 7.640
Authors: Christopher Ng'andwe; John J Lowe; Paula J Richards; Lara Hause; Charles Wood; Peter C Angeletti Journal: BMC Infect Dis Date: 2007-07-16 Impact factor: 3.090