Literature DB >> 23474289

Roles of the epoxygenase CYP2J2 in the endothelium.

Ara Askari1, Scott J Thomson, Matthew L Edin, Darryl C Zeldin, David Bishop-Bailey.   

Abstract

Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are inactivated by soluble epoxide hydrolase (sEH), which converts them in to their corresponding dihydroxyeicosatrienoic acids (DHETs). CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs it produces have been shown to have a diverse range of effects on the vasculature, including the regulation of inflammation, vascular tone, cellular proliferation, angiogenesis, and metabolism. This review will examine these established and emerging roles of CYP2J2 in the biology of vascular endothelial cells.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Dilation; Endothelial; Epoxygenase; Inflammation; Metabolism

Mesh：

Substances：

Year:  2013        PMID： 23474289      PMCID： PMC3711961          DOI： 10.1016/j.prostaglandins.2013.02.003

Source DB:  PubMed          Journal:  Prostaglandins Other Lipid Mediat        ISSN： 1098-8823            Impact factor:   3.072


  96 in total

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Journal:  Life Sci       Date:  2008-07-12       Impact factor: 5.037

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Authors:  Florian Krötz; Tobias Riexinger; Martin A Buerkle; Kasem Nithipatikom; Torsten Gloe; Hae-Young Sohn; William B Campbell; Ulrich Pohl
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-01-08       Impact factor: 8.311

8.  Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia.

Authors:  Karni S Moshal; Darryl C Zeldin; Srinivas D Sithu; Utpal Sen; Neetu Tyagi; Munish Kumar; William M Hughes; Naira Metreveli; Dorothea S E Rosenberger; Mahavir Singh; Thomas P Vacek; Walter E Rodriguez; Adeagbo Ayotunde; Suresh C Tyagi
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Authors:  Jonas Bystrom; Jessica A Wray; Mary C Sugden; Mark J Holness; Karen E Swales; Timothy D Warner; Matthew L Edin; Darryl C Zeldin; Derek W Gilroy; David Bishop-Bailey
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  19 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

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Authors:  G Proietti; K K Abelak; D Bishop-Bailey; A Macchiarulo; I Nobeli
Journal:  J Mol Model       Date:  2016-10-28       Impact factor: 1.810

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4.  Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice.

Authors:  Yan Gong; Yohei Tomita; Matthew L Edin; Anli Ren; Minji Ko; Jay Yang; Edward Bull; Darryl C Zeldin; Ann Hellström; Zhongjie Fu; Lois E H Smith
Journal:  Metabolism       Date:  2022-07-19       Impact factor: 13.934

5.  CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.

Authors:  Nader G Abraham; Komal Sodhi; Anne M Silvis; Luca Vanella; Gaia Favero; Rita Rezzani; Craig Lee; Darryl C Zeldin; Michal L Schwartzman
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Review 6.  Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation.

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7.  Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.

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9.  Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data.

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Authors:  Scott Thomson; Matthew L Edin; Fred B Lih; Michael Davies; Muhammad M Yaqoob; Bruce D Hammock; Derek Gilroy; Darryl C Zeldin; David Bishop-Bailey
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