Literature DB >> 2347400

Presence of specific binding sites for [3H]sarcophytol-A in cultured human skin fibroblasts.

T Nakagane1, R Ishitani.   

Abstract

The presence of specific binding sites for [3H]sarcophytol-A in human skin fibroblasts was examined using biochemical and morphological methods. The displacement studies clearly revealed that high (KD = 31.0 nM) and low (KD = 6.05 microM) affinity sites were present in the intact cells. Moreover, autoradiographic studies using light microscopy revealed that the specific binding sites may exist in both the cytoplasm and the nuclei.

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Year:  1990        PMID： 2347400     DOI： 10.1007/bf01954242

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Marine terpenes and terpenoids. V. Oxidation of sarcophytol A, a potent anti-tumor-promoter from the soft coral Sarcophyton glaucum.

Authors:  M Kobayashi; K Kondo; K Osabe; H Mitsuhashi
Journal:  Chem Pharm Bull (Tokyo)       Date:  1988-07       Impact factor: 1.645

Review 2.  A human retinoic acid receptor which belongs to the family of nuclear receptors.

Authors:  M Petkovich; N J Brand; A Krust; P Chambon
Journal:  Nature       Date:  1987 Dec 3-9       Impact factor: 49.962

3.  Identification of a receptor for the morphogen retinoic acid.

Authors:  V Giguere; E S Ong; P Segui; R M Evans
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

4.  Selective labelling of high affinity 5-hydroxytryptamine1 receptors in whole rat brain.

Authors:  S Yoshikawa; R Ishitani
Journal:  Neuropharmacology       Date:  1984-10       Impact factor: 5.250

5.  Characterization of the retinol and retinoic acid binding proteins in the human prostate.

Authors:  D Boyd; L Beynon; G D Chisholm; F K Habib
Journal:  Cancer Res       Date:  1984-12       Impact factor: 12.701

6.  Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin.

Authors:  H Fujiki; M Suganuma; H Suguri; S Yoshizawa; K Takagi; M Kobayashi
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

7.  Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids.

Authors:  A D Horowitz; E Greenebaum; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

8.  AUTORADIOGRAPHY OF SOLUBLE MATERIALS.

Authors:  O L MILLER; G E STONE; D M PRESCOTT
Journal:  J Cell Biol       Date:  1964-12       Impact factor: 10.539
  8 in total

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