Literature DB >> 2347397

The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice.

J M Stark1, S K Jackson, S Taylor, I Davies, J L Harwood.   

Abstract

The effects of endotoxin on mouse liver phospholipid fatty acid composition have been investigated. Administration of endotoxin from Salmonella abortus equi led to a decrease in the polyunsaturated fatty acid content of livers from mice sensitized with Bacille Calmette Guérin (BCG). The content of arachidonic acid fell significantly in both the phosphatidylcholine and phosphatidylinositol fractions whereas in the phosphatidylethanolamine fraction the linoleic acid content was significantly reduced. The polyunsaturated fatty acids were replaced by increased amounts of oleic acid and palmitic acid, leading to a reduction in the polyunsaturated to saturated fatty acid ratio.

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Year:  1990        PMID： 2347397     DOI： 10.1007/bf01954235

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.

Authors:  E SUTER; E M KIRSANOW
Journal:  Immunology       Date:  1961-10       Impact factor: 7.397

2.  The rapid incorporation of phosphate into mitochondrial lipids.

Authors:  J GARBUS; H F DELUCA; M E LOOMANS; F M STRONG
Journal:  J Biol Chem       Date:  1963-01       Impact factor: 5.157

3.  Phospholipid composition of membranes in the tumor cell.

Authors:  L D Bergelson; E V Dyatlovitskaya; T I Torkhovskaya; I B Sorokina; N P Gorkova
Journal:  Biochim Biophys Acta       Date:  1970-07-14

4.  Hepatocyte function in sepsis: Kupffer cells mediate a biphasic protein synthesis response in hepatocytes after exposure to endotoxin or killed Escherichia coli.

Authors:  M A West; G A Keller; B J Hyland; F B Cerra; R L Simmons
Journal:  Surgery       Date:  1985-09       Impact factor: 3.982

5.  Is platelet activating factor (PAF) a mediator of endotoxin shock?

Authors:  Z Terashita; Y Imura; K Nishikawa; S Sumida
Journal:  Eur J Pharmacol       Date:  1985-02-26       Impact factor: 4.432

6.  The role of prostaglandins in sepsis.

Authors:  J R Fletcher
Journal:  Scand J Infect Dis Suppl       Date:  1982

7.  Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.

Authors:  S K Jackson; J M Stark; S Taylor; J L Harwood
Journal:  Br J Exp Pathol       Date:  1989-08

8.  Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-hete) during endotoxemia in unanesthetized sheep.

Authors:  M L Ogletree; J A Oates; K L Brigham; W C Hubbard
Journal:  Prostaglandins       Date:  1982-04

9.  Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin.

Authors:  M A Freudenberg; D Keppler; C Galanos
Journal:  Infect Immun       Date:  1986-03       Impact factor: 3.441
  9 in total
  2 in total

1.  Interferon-gamma and polyunsaturated fatty acids increase the binding of lipopolysaccharide to macrophages.

Authors:  H Darmani; J Parton; J L Harwood; S K Jackson
Journal:  Int J Exp Pathol       Date:  1994-10       Impact factor: 1.925

2.  Interferon-gamma increases macrophage phospholipid polyunsaturation: a possible mechanism of endotoxin sensitivity.

Authors:  S K Jackson; H Darmani; J M Stark; J L Harwood
Journal:  Int J Exp Pathol       Date:  1992-12       Impact factor: 1.925
  2 in total

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