| Literature DB >> 2347393 |
B L Miller1, K M Lin, A Djenderedjian, C Tang, E Hill, P Fu, C Nuccio, D J Jenden.
Abstract
The influence of oral lithium on the concentration of red blood cell choline (Ch), lecithin, glycerophosphorylcholine (GPCh) and phosphorylcholine (PCh) was studied. The concentration of RBC Ch was significantly elevated and the concentration of lecithin, GPCh and PCh significantly depressed in 16 patients on oral lithium compared to 9 age-matched controls. We conclude that lithium markedly depletes the red blood cell of choline containing compounds including lecithin. These changes may be responsible for both the therapeutic efficacy and the toxicity of lithium.Entities:
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Year: 1990 PMID： 2347393 DOI： 10.1007/bf01954227
Source DB: PubMed Journal: Experientia ISSN： 0014-4754