Literature DB >> 23473679

Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide.

Haixun Guo1, Yubin Miao.   

Abstract

The purpose of this study was to determine the melanoma targeting property of (177)Lu-DOTA-GGNle-CycMSHhex in B16/F1 melanoma-bearing C57 mice. (177)Lu-DOTA-GGNle-CycMSHhex exhibited high receptor-mediated melanoma uptake and fast urinary clearance. The tumor uptake of (177)Lu-DOTA-GGNle-CycMSHhex was 20.25 ± 4.59 and 21.63 ± 6.27% ID/g at 0.5 and 2h post-injection, respectively. Approximately 83% of injected dose cleared out the body via urinary system at 2h post-injection. (177)Lu-DOTA-GGNle-CycMSHhex showed high tumor to normal organ uptake ratios except for the kidneys. The tumor/kidney uptake ratios of (177)Lu-DOTA-GGNle-CycMSHhex were 2.76 and 1.74 at 2 and 24h post-injection. The melanoma lesions were clearly visualized by SPECT/CT using (177)Lu-DOTA-GGNle-CycMSHhex as an imaging probe at 2h post-injection. Overall, high melanoma uptake coupled with fast urinary clearance of (177)Lu-DOTA-GGNle-CycMSHhex underscored its potential for melanoma treatment in the future.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23473679      PMCID： PMC3635095          DOI： 10.1016/j.bmcl.2013.02.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  30 in total

1.  A novel DOTA-alpha-melanocyte-stimulating hormone analog for metastatic melanoma diagnosis.

Authors:  Sylvie Froidevaux; Martine Calame-Christe; Heidi Tanner; Lazar Sumanovski; Alex N Eberle
Journal:  J Nucl Med       Date:  2002-12       Impact factor: 10.057

2.  Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.

Authors:  J Chen; Z Cheng; N K Owen; T J Hoffman; Y Miao; S S Jurisson; T P Quinn
Journal:  J Nucl Med       Date:  2001-12       Impact factor: 10.057

3.  Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues.

Authors:  J Chen; Z Cheng; T J Hoffman; S S Jurisson; T P Quinn
Journal:  Cancer Res       Date:  2000-10-15       Impact factor: 12.701

4.  Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models.

Authors:  Yubin Miao; Nellie K Owen; Darrell R Fisher; Timothy J Hoffman; Thomas P Quinn
Journal:  J Nucl Med       Date:  2005-01       Impact factor: 10.057

5.  Melanoma targeting with DOTA-alpha-melanocyte-stimulating hormone analogs: structural parameters affecting tumor uptake and kidney uptake.

Authors:  Sylvie Froidevaux; Martine Calame-Christe; Heidi Tanner; Alex N Eberle
Journal:  J Nucl Med       Date:  2005-05       Impact factor: 10.057

6.  A gallium-labeled DOTA-alpha-melanocyte- stimulating hormone analog for PET imaging of melanoma metastases.

Authors:  Sylvie Froidevaux; Martine Calame-Christe; Jochen Schuhmacher; Heidi Tanner; Rainer Saffrich; Markus Henze; Alex N Eberle
Journal:  J Nucl Med       Date:  2004-01       Impact factor: 10.057

7.  Design and characterization of alpha-melanotropin peptide analogs cyclized through rhenium and technetium metal coordination.

Authors:  M F Giblin; N Wang; T J Hoffman; S S Jurisson; T P Quinn
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

8.  Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues.

Authors:  Zhen Cheng; Jianqing Chen; Yubin Miao; Nellie K Owen; Thomas P Quinn; Silvia S Jurisson
Journal:  J Med Chem       Date:  2002-07-04       Impact factor: 7.446

9.  In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy.

Authors:  Yubin Miao; Nellie K Owen; Donna Whitener; Fabio Gallazzi; Timothy J Hoffman; Thomas P Quinn
Journal:  Int J Cancer       Date:  2002-10-10       Impact factor: 7.396

10.  Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues.

Authors:  Yubin Miao; Donna Whitener; Weiwei Feng; Nellie K Owen; Jianqing Chen; Thomas P Quinn
Journal:  Bioconjug Chem       Date:  2003 Nov-Dec       Impact factor: 4.774
View more
  14 in total

Review 1.  PET and SPECT imaging of melanoma: the state of the art.

Authors:  Weijun Wei; Emily B Ehlerding; Xiaoli Lan; Quanyong Luo; Weibo Cai
Journal:  Eur J Nucl Med Mol Imaging       Date:  2017-10-30       Impact factor: 9.236

2.  68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging.

Authors:  Jianquan Yang; Jingli Xu; Rene Gonzalez; Thomas Lindner; Clemens Kratochwil; Yubin Miao
Journal:  Sci Transl Med       Date:  2018-11-07       Impact factor: 17.956

Review 3.  Production of (177)Lu for Targeted Radionuclide Therapy: Available Options.

Authors:  Ashutosh Dash; Maroor Raghavan Ambikalmajan Pillai; Furn F Knapp
Journal:  Nucl Med Mol Imaging       Date:  2015-02-17

4.  Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting.

Authors:  Jianquan Yang; Jingli Xu; Lina Cheuy; Rene Gonzalez; Darrell R Fisher; Yubin Miao
Journal:  Mol Pharm       Date:  2019-02-25       Impact factor: 4.939

5.  Novel [99mTc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake.

Authors:  Zheng Qiao; Jingli Xu; Rene Gonzalez; Yubin Miao
Journal:  Mol Pharm       Date:  2020-07-28       Impact factor: 4.939

6.  Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized α-Melanocyte-Stimulating Hormone Peptide.

Authors:  Jingli Xu; Jianquan Yang; Rene Gonzalez; Darrell R Fisher; Yubin Miao
Journal:  Cancer Biother Radiopharm       Date:  2019-10-23       Impact factor: 3.099

7.  The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides.

Authors:  Jingli Xu; Fabio Gallazzi; Darrell R Fisher; Rene Gonzalez; Yubin Miao
Journal:  Cancer Biother Radiopharm       Date:  2021-11-11       Impact factor: 3.099

8.  Incidental Synchronous 99mTc-HYNIC-TOC Avid Lesion of the Neck in a Patient with Metastatic Melanoma: A Metastatic Lymph Node or a Carotid Body Tumor Masquerading As a Lymph Node?

Authors:  Vahid Roshanravan; Ehsan Soltani; Ehsan Hasanzadeh Haddad; Ramin Sadeghi; Azadeh Sahebkari; Mahdi Mottaghi; Atena Aghaee
Journal:  Asia Ocean J Nucl Med Biol       Date:  2022

9.  Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of Humanized Antibodies with 188Rhenium.

Authors:  Kevin J H Allen; Rubin Jiao; Mackenzie E Malo; Ekaterina Dadachova
Journal:  Cancer Biother Radiopharm       Date:  2018-07-16       Impact factor: 3.099

10.  Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting.

Authors:  Jingli Xu; Zheng Qiao; Rene Gonzalez; Yubin Miao
Journal:  Bioorg Med Chem Lett       Date:  2020-10-24       Impact factor: 2.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.