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Literature DB >> 23473587

Drug repurposing a reality: from computers to the clinic.

Naiem T Issa, Jordan Kruger, Stephen W Byers, Sivanesan Dakshanamurthy.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23473587 PMCID： PMC4489563 DOI： 10.1586/ecp.12.79

Source DB: PubMed Journal: Expert Rev Clin Pharmacol ISSN： 1751-2433 Impact factor: 5.045

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19 in total

1. The price of innovation: new estimates of drug development costs.

Authors: Joseph A DiMasi; Ronald W Hansen; Henry G Grabowski
Journal: J Health Econ Date: 2003-03 Impact factor: 3.883

2. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Authors: Justin Lamb; Emily D Crawford; David Peck; Joshua W Modell; Irene C Blat; Matthew J Wrobel; Jim Lerner; Jean-Philippe Brunet; Aravind Subramanian; Kenneth N Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A Armstrong; Stephen J Haggarty; Paul A Clemons; Ru Wei; Steven A Carr; Eric S Lander; Todd R Golub
Journal: Science Date: 2006-09-29 Impact factor: 47.728

3. Pipelines turn to biotech.

Authors: Stacy Lawrence
Journal: Nat Biotechnol Date: 2007-12 Impact factor: 54.908

4. The human disease network.

Authors: Kwang-Il Goh; Michael E Cusick; David Valle; Barton Childs; Marc Vidal; Albert-László Barabási
Journal: Proc Natl Acad Sci U S A Date: 2007-05-14 Impact factor: 11.205

5. Drug-target network.

Authors: Muhammed A Yildirim; Kwang-Il Goh; Michael E Cusick; Albert-László Barabási; Marc Vidal
Journal: Nat Biotechnol Date: 2007-10 Impact factor: 54.908

Review 6. Computational methods for biomolecular docking.

Authors: T Lengauer; M Rarey
Journal: Curr Opin Struct Biol Date: 1996-06 Impact factor: 6.809

7. Relating protein pharmacology by ligand chemistry.

Authors: Michael J Keiser; Bryan L Roth; Blaine N Armbruster; Paul Ernsberger; John J Irwin; Brian K Shoichet
Journal: Nat Biotechnol Date: 2007-02 Impact factor: 54.908

8. Human disease-drug network based on genomic expression profiles.

Authors: Guanghui Hu; Pankaj Agarwal
Journal: PLoS One Date: 2009-08-06 Impact factor: 3.240

9. C²Maps: a network pharmacology database with comprehensive disease-gene-drug connectivity relationships.

Authors: Hui Huang; Xiaogang Wu; Ragini Pandey; Jiao Li; Guoling Zhao; Sara Ibrahim; Jake Y Chen
Journal: BMC Genomics Date: 2012-10-26 Impact factor: 3.969

10. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Authors: Sarah L Kinnings; Nina Liu; Nancy Buchmeier; Peter J Tonge; Lei Xie; Philip E Bourne
Journal: PLoS Comput Biol Date: 2009-07-03 Impact factor: 4.475

7 in total

Drug repurposing a reality: from computers to the clinic.

1. The price of innovation: new estimates of drug development costs.

2. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

3. Pipelines turn to biotech.

4. The human disease network.

5. Drug-target network.

Review 6. Computational methods for biomolecular docking.

7. Relating protein pharmacology by ligand chemistry.

8. Human disease-drug network based on genomic expression profiles.

9. C²Maps: a network pharmacology database with comprehensive disease-gene-drug connectivity relationships.

10. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Review 1. A review of connectivity map and computational approaches in pharmacogenomics.

2. An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors.

Review 3. Computational polypharmacology: a new paradigm for drug discovery.

4. SwissTargetPrediction: a web server for target prediction of bioactive small molecules.

Review 5. Recent Advances in Application of Computer-Aided Drug Design in Anti-Influenza A Virus Drug Discovery.

6. Dual targeting of 3CL^pro and PL^pro of SARS-CoV-2: A novel structure-based design approach to treat COVID-19.

Review 7. Application of the SwissDrugDesign Online Resources in Virtual Screening.