Literature DB >> 23473025

Novel SIRT1 mutation linked to autoimmune diabetes in humans.

Jing W Hughes1, Kevan C Herold.   

Abstract

Sirtuins are best known for their role in aging but also regulate many different biological processes. A study in this issue of Cell Metabolism (Biason-Lauber et al., 2013) now identifies a mutation in human SIRT1 causing a familial form of autoimmune diabetes.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23473025      PMCID： PMC4168898          DOI： 10.1016/j.cmet.2013.02.014

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.

Authors:  Ulf H Beier; Liqing Wang; Rongxiang Han; Tatiana Akimova; Yujie Liu; Wayne W Hancock
Journal:  Sci Signal       Date:  2012-06-19       Impact factor: 8.192

2.  Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.

Authors:  Nirmala Hariharan; Yasuhiro Maejima; Jun Nakae; Jihye Paik; Ronald A Depinho; Junichi Sadoshima
Journal:  Circ Res       Date:  2010-10-14       Impact factor: 17.367

3.  A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Authors:  In Hye Lee; Liu Cao; Raul Mostoslavsky; David B Lombard; Jie Liu; Nicholas E Bruns; Maria Tsokos; Frederick W Alt; Toren Finkel
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-22       Impact factor: 11.205

4.  Identification of a SIRT1 mutation in a family with type 1 diabetes.

Authors:  Anna Biason-Lauber; Marianne Böni-Schnetzler; Basil P Hubbard; Karim Bouzakri; Andrea Brunner; Claudia Cavelti-Weder; Cornelia Keller; Monika Meyer-Böni; Daniel T Meier; Caroline Brorsson; Katharina Timper; Gil Leibowitz; Andrea Patrignani; Remy Bruggmann; Gino Boily; Henryk Zulewski; Andreas Geier; Jennifer M Cermak; Peter Elliott; James L Ellis; Christoph Westphal; Urs Knobel; Jyrki J Eloranta; Julie Kerr-Conte; François Pattou; Daniel Konrad; Christian M Matter; Adriano Fontana; Gerhard Rogler; Ralph Schlapbach; Camille Regairaz; José M Carballido; Benjamin Glaser; Michael W McBurney; Flemming Pociot; David A Sinclair; Marc Y Donath
Journal:  Cell Metab       Date:  2013-03-05       Impact factor: 27.287

5.  sirt1-null mice develop an autoimmune-like condition.

Authors:  Jedon Sequeira; Gino Boily; Stephanie Bazinet; Sarah Saliba; Xiaohong He; Karen Jardine; Christopher Kennedy; William Staines; Colin Rousseaux; Rudi Mueller; Michael W McBurney
Journal:  Exp Cell Res       Date:  2008-07-23       Impact factor: 3.905

6.  Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.

Authors:  Hye Seung Jung; Kun Wook Chung; Jeong Won Kim; Jin Kim; Masaaki Komatsu; Keiji Tanaka; Yen Hoang Nguyen; Tong Mook Kang; Kun-Ho Yoon; Ji-Won Kim; Yeon Taek Jeong; Myoung Sook Han; Moon-Kyu Lee; Kwang-Won Kim; Jaekyoon Shin; Myung-Shik Lee
Journal:  Cell Metab       Date:  2008-10       Impact factor: 27.287

7.  SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

Authors:  Cheng Sun; Fang Zhang; Xinjian Ge; Tingting Yan; Xingmiao Chen; Xianglin Shi; Qiwei Zhai
Journal:  Cell Metab       Date:  2007-10       Impact factor: 27.287

8.  The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.

Authors:  Jinping Zhang; Sang-Myeong Lee; Stephen Shannon; Beixue Gao; Weimin Chen; An Chen; Rohit Divekar; Michael W McBurney; Helen Braley-Mullen; Habib Zaghouani; Deyu Fang
Journal:  J Clin Invest       Date:  2009-10       Impact factor: 14.808

9.  Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway.

Authors:  Ji-Hyun Lee; Mi-Young Song; Eun-Kyung Song; Eun-Kyung Kim; Woo Sung Moon; Myung-Kwan Han; Jin-Woo Park; Kang-Beom Kwon; Byung-Hyun Park
Journal:  Diabetes       Date:  2008-11-13       Impact factor: 9.461

10.  The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Authors:  Xiumei Guo; Mehmet Kesimer; Gökhan Tolun; Xunhai Zheng; Qing Xu; Jing Lu; John K Sheehan; Jack D Griffith; Xiaoling Li
Journal:  Sci Rep       Date:  2012-09-07       Impact factor: 4.379
  10 in total

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