OBJECTIVE: The aim of this study was to determine the serum levels of visfatin, adiponectin, and insulin resistance (IR) in patients with hepatitis C virus (HCV) infection and their relations to the biochemical markers of hepatitis C. MATERIALS AND METHODS: This study was carried out on 40 HCV-infected patients and 40 sex/age/BMI-matched healthy adults. Lipid profile, liver function tests, IR, serum adiponectin, and visfatin of all patients were examined. Correlations between IR, adiponectin, visfatin, and other variables were analyzed. RESULTS: The levels of visfatin and adiponectin were significantly lower in HCV patients compared with healthy controls. However, IR of HCV patients were higher than those of healthy controls. IR was significantly correlated to triglycerides, visfatin was closely related to low-density lipoprotein cholesterol, whereas adiponectin was associated with high-density lipoprotein cholesterol. These results suggest that IR, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic HCV-infected patients. CONCLUSION: IR, adiponectin, and visfatin were related to several metabolic markers of HCV, suggesting the characteristics of HCV-related metabolic abnormalities.
OBJECTIVE: The aim of this study was to determine the serum levels of visfatin, adiponectin, and insulin resistance (IR) in patients with hepatitis C virus (HCV) infection and their relations to the biochemical markers of hepatitis C. MATERIALS AND METHODS: This study was carried out on 40 HCV-infectedpatients and 40 sex/age/BMI-matched healthy adults. Lipid profile, liver function tests, IR, serum adiponectin, and visfatin of all patients were examined. Correlations between IR, adiponectin, visfatin, and other variables were analyzed. RESULTS: The levels of visfatin and adiponectin were significantly lower in HCVpatients compared with healthy controls. However, IR of HCVpatients were higher than those of healthy controls. IR was significantly correlated to triglycerides, visfatin was closely related to low-density lipoprotein cholesterol, whereas adiponectin was associated with high-density lipoprotein cholesterol. These results suggest that IR, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic HCV-infectedpatients. CONCLUSION: IR, adiponectin, and visfatin were related to several metabolic markers of HCV, suggesting the characteristics of HCV-related metabolic abnormalities.
Authors: Michał Kukla; Brygida Adamek; Marek Waluga; Marzena Zalewska-Ziob; Janusz Kasperczyk; Andrzej Gabriel; Włodzimierz Mazur; Barbara Sobala-Szczygieł; Rafał J Bułdak; Wojciech Zajęcki; Lucjan Kępa; Katarzyna Ziora; Krystyna Żwirska-Korczala; Andrzej Wiczkowski; Marek Hartleb Journal: Biomed Res Int Date: 2014-07-10 Impact factor: 3.411
Authors: Ying Xiu Toh; Victor Gan; Thavamalar Balakrishnan; Roland Zuest; Michael Poidinger; Solomonraj Wilson; Ramapraba Appanna; Tun Linn Thein; Adrian Kheng-Yeow Ong; Lee Ching Ng; Yee Sin Leo; Katja Fink Journal: Front Immunol Date: 2014-08-14 Impact factor: 7.561
Authors: Michał Kukla; Marzena Zalewska-Ziob; Brygida Adamek; Janusz Kasperczyk; Rafał J Bułdak; Tomasz Sawczyn; Dominika Stygar; Barbara Sobala-Szczygieł; Marta Stachowska; Andrzej Gabriel; Andrzej Wiczkowski Journal: Clin Exp Hepatol Date: 2019-05-13