Literature DB >> 23470202

Construction of spiro-tetrahydroquinolines via intramolecular dearomatization of quinolines: free of a preinstalled activation group.

Shou-Guo Wang1, Wei Zhang, Shu-Li You.   

Abstract

A highly efficient synthesis of spiro-tetrahydroquinolines (up to 99% yield) has been realized via cascade hydrogenative dearomatization of quinoline and intramolecular aza-Friedel-Crafts alkylation reaction.

Entities:  

Year:  2013        PMID： 23470202     DOI： 10.1021/ol4002416

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Self-Assembly of a Library of Polyborate Chiral Anions for Asymmetric Catalytic Quinoline Reduction.

Authors:  Aman A Desai; Yong Guan; Aaron L Odom; Supriyo Majumder; William D Wulff
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

2.  Evidence for Simultaneous Dearomatization of Two Aromatic Rings under Mild Conditions in Cu(I)-Catalyzed Direct Asymmetric Dearomatization of Pyridine.

Authors:  Michael W Gribble; Richard Y Liu; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2020-06-11       Impact factor: 15.419

3.  Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench.

Authors:  Nicholas Carter; Xiabing Li; Lewis Reavey; Anthony J H M Meijer; Iain Coldham
Journal:  Chem Sci       Date:  2017-12-14       Impact factor: 9.825

Review 4.  The Cascade [1,5]-Hydride Shift/Intramolecular C(sp3)-H Activation: A Powerful Approach to the Construction of Spiro-Tetrahydroquinoline Skeleton.

Authors:  Hongmei Liu; Yunyun Quan; Long Xie; Xiang Li; Xin Xie
Journal:  Front Chem       Date:  2022-04-07       Impact factor: 5.545
  4 in total

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