RATIONALE: Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (fMRI) to study right frontal responses to stop signals in heavy drinking subjects with and without FHA, and as a function of alcohol exposure. METHODS:Twenty-two family history-positive (FHP; age = 22.7 years, SD = 1.9) and 18 family history-negative (FHN; age = 23.7, SD = 1.8) subjects performed the SST in fMRI in two randomized visits: once during intravenous infusion of alcohol, clamped at a steady-state breath alcohol (BrAC) concentration of 60 mg/dL, and once during infusion of placebo saline. An independent reference group (n = 13, age = 23.7, SD = 1.8) was used to identify a priori right prefrontal regions activated by successful inhibition (Inh) trials, relative to "Go" trials that carried no need for inhibition [Inh > Go]. RESULTS:FHA interacted with alcohol exposure in right prefrontal cortex, where alcohol reduced [Inh > Go] activation in FHN subjects but not in FHP subjects. Within this right frontal cortical region, stop-signal reaction time also correlated negatively with [Inh > Go] activation, suggesting that the [Inh > Go] activity was related to inhibitory behavior. CONCLUSIONS: The results are consistent with the low level of response theory (Schuckit, J Stud Alcohol 55:149-158, 1980; Quinn and Fromme, Alcohol Clin Exp Res 35:1759-1770, 2011), with FHP being less sensitive to alcohol's effects.
RCT Entities:
RATIONALE: Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE: Employ functional magnetic resonance imaging (fMRI) to study right frontal responses to stop signals in heavy drinking subjects with and without FHA, and as a function of alcohol exposure. METHODS: Twenty-two family history-positive (FHP; age = 22.7 years, SD = 1.9) and 18 family history-negative (FHN; age = 23.7, SD = 1.8) subjects performed the SST in fMRI in two randomized visits: once during intravenous infusion of alcohol, clamped at a steady-state breathalcohol (BrAC) concentration of 60 mg/dL, and once during infusion of placebo saline. An independent reference group (n = 13, age = 23.7, SD = 1.8) was used to identify a priori right prefrontal regions activated by successful inhibition (Inh) trials, relative to "Go" trials that carried no need for inhibition [Inh > Go]. RESULTS:FHA interacted with alcohol exposure in right prefrontal cortex, where alcohol reduced [Inh > Go] activation in FHN subjects but not in FHP subjects. Within this right frontal cortical region, stop-signal reaction time also correlated negatively with [Inh > Go] activation, suggesting that the [Inh > Go] activity was related to inhibitory behavior. CONCLUSIONS: The results are consistent with the low level of response theory (Schuckit, J Stud Alcohol 55:149-158, 1980; Quinn and Fromme, Alcohol Clin Exp Res 35:1759-1770, 2011), with FHP being less sensitive to alcohol's effects.
Authors: Susan F Tapert; Erick H Cheung; Gregory G Brown; Lawrence R Frank; Martin P Paulus; Alecia D Schweinsburg; M J Meloy; Sandra A Brown Journal: Arch Gen Psychiatry Date: 2003-07
Authors: Jiongjiong Wang; Daniel J Licht; Geon-Ho Jahng; Chia-Shang Liu; Joan T Rubin; John Haselgrove; Robert A Zimmerman; John A Detre Journal: J Magn Reson Imaging Date: 2003-10 Impact factor: 4.813
Authors: Christopher D Chambers; Mark A Bellgrove; Mark G Stokes; Tracy R Henderson; Hugh Garavan; Ian H Robertson; Adam P Morris; Jason B Mattingley Journal: J Cogn Neurosci Date: 2006-03 Impact factor: 3.225
Authors: Jaime S Ide; Simon Zhornitsky; Herta H Chao; Sheng Zhang; Sien Hu; Wuyi Wang; John H Krystal; Chiang-Shan R Li Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-05-03
Authors: Gabriela Gan; Alvaro Guevara; Michael Marxen; Maike Neumann; Elisabeth Jünger; Andrea Kobiella; Eva Mennigen; Maximilian Pilhatsch; Daniel Schwarz; Ulrich S Zimmermann; Michael N Smolka Journal: Biol Psychiatry Date: 2014-01-15 Impact factor: 13.382
Authors: Jessica Weafer; Mario Dzemidzic; William Eiler; Brandon G Oberlin; Yang Wang; David A Kareken Journal: Psychiatry Res Date: 2015-05-07 Impact factor: 3.222
Authors: Gabriela Gan; Philipp Sterzer; Michael Marxen; Ulrich S Zimmermann; Michael N Smolka Journal: Neuropsychopharmacology Date: 2015-05-14 Impact factor: 7.853
Authors: Nicole M Strang; Eric D Claus; Vijay A Ramchandani; Ariel Graff-Guerrero; Isabelle Boileau; Christian S Hendershot Journal: Psychopharmacology (Berl) Date: 2014-08-12 Impact factor: 4.530
Authors: Daniel S Albrecht; David A Kareken; Bradley T Christian; Mario Dzemidzic; Karmen K Yoder Journal: Synapse Date: 2014-02-28 Impact factor: 2.562