[Nonlinear effects in kinetics of blood coagulation].

A linear mathematical model of the kinetics of humoral system of hemocoagulation is presented in the works by Levin (1966), Moro a. Brakhucha-Reyd (1969), Martoran a. Moro (1974). Present paper considers a nonlinear mathematical model of the intrinsic path of hemocoagulation which takes into account the effect of positive feed back which is related to the action of factors Va and VIIIa as co-factors. It is found that the intrinsic path of hemocoagulation normally functions as an amplifier cascade, if the wall damage is above some threshold value. When the damage is below the threshold value the intrinsic path of hemocoagulation does not function.