Literature DB >> 2346727

Post-hepatitic aplastic anaemia in children in Taiwan, a hepatitis prevalent area.

D C Liang1, K H Lin, D T Lin, C P Yang, K L Hung, K S Lin.   

Abstract

Aplastic anaemia is a rare but serious complication of hepatitis, and hepatitis is an unusual cause of aplastic anaemia in children in the West. However, the relative frequencies of acquired aplastic anaemia in children in Taiwan, a hepatitis prevalent area, differ from those in the West, in the very high frequency of post-hepatitic aplastic anaemia (23.9% of all cases of aplastic anaemia). This may account for the higher incidence of aplastic anaemia in children in Taiwan. Although the prognosis of post-hepatitic severe aplastic anaemia was very poor, the present study using bone marrow transplantation, antithymocyte (or antilymphocyte) globulin, high-dose methylprednisolone and cyclosporin, etc., has improved the response rate and the survival.

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Year:  1990        PMID: 2346727     DOI: 10.1111/j.1365-2141.1990.tb06339.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  6 in total

1.  Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus.

Authors:  D Binder; J Fehr; H Hengartner; R M Zinkernagel
Journal:  J Exp Med       Date:  1997-02-03       Impact factor: 14.307

2.  Severe aplastic anemia associated with seronegative community-acquired hepatitis C virus infection.

Authors:  A Gruber; L Grillner; H Norder; L Magnius; M Björkholm
Journal:  Ann Hematol       Date:  1993-03       Impact factor: 3.673

3.  Acquired aplastic anaemia: still a serious disease.

Authors:  D K Webb; I M Hann; J M Chessells
Journal:  Arch Dis Child       Date:  1991-07       Impact factor: 3.791

4.  Overproduction of inhibitory hematopoietic cytokines by lipopolysaccharide-activated peripheral blood mononuclear cells in patients with aplastic anemia.

Authors:  H C Hsu; W H Tsai; L Y Chen; M L Hsu; C H Ho; C K Lin; S Y Wang
Journal:  Ann Hematol       Date:  1995-12       Impact factor: 3.673

5.  Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.

Authors:  Nadine Althof; J Lindsay Whitton
Journal:  J Virol       Date:  2012-12-26       Impact factor: 5.103

6.  Aplastica anemia and viral hepatitis.

Authors:  Laura Cudillo
Journal:  Mediterr J Hematol Infect Dis       Date:  2009-12-26       Impact factor: 2.576

  6 in total

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