BACKGROUND: Apart from a recent study reporting a 2- to 3-fold increased risk of multiple sclerosis (MS) among women and men who were delivered by Cesarean section (C-section), little attention has been given to the possible association between mode of delivery and the risk of MS. OBJECTIVES: We studied the association between C-section and risk of MS, in a cohort of 1.7 million Danes born from 1973 to 2005. METHODS: Information on C-section and MS was obtained from the Danish Medical Birth Register and the Danish MS Register, respectively. The association between C-section and MS was evaluated by means of MS incidence rate ratios (RR) with 95% confidence intervals (CI) obtained in log-linear Poisson regression analyses. RESULTS: There were 930 cases of MS in the study cohort, of whom 80 (9%) were delivered by C-section. Overall, we found there was no significant association between C-section and risk of MS (RR = 1.17; 0.92-1.46). Analyses stratified by sex revealed no unusual risk of MS for women (RR = 1.08: 0.80-1.42) nor men (RR = 1.37: 0.91-1.98). A supplementary sibling-matched Cox regression analysis likewise suggested there was no excess risk of MS in persons delivered by C-section (HR = 1.03; 0.63-1.69). CONCLUSIONS: Mode of delivery appears to be unimportant in relation to MS development in the offspring.
BACKGROUND: Apart from a recent study reporting a 2- to 3-fold increased risk of multiple sclerosis (MS) among women and men who were delivered by Cesarean section (C-section), little attention has been given to the possible association between mode of delivery and the risk of MS. OBJECTIVES: We studied the association between C-section and risk of MS, in a cohort of 1.7 million Danes born from 1973 to 2005. METHODS: Information on C-section and MS was obtained from the Danish Medical Birth Register and the Danish MS Register, respectively. The association between C-section and MS was evaluated by means of MS incidence rate ratios (RR) with 95% confidence intervals (CI) obtained in log-linear Poisson regression analyses. RESULTS: There were 930 cases of MS in the study cohort, of whom 80 (9%) were delivered by C-section. Overall, we found there was no significant association between C-section and risk of MS (RR = 1.17; 0.92-1.46). Analyses stratified by sex revealed no unusual risk of MS for women (RR = 1.08: 0.80-1.42) nor men (RR = 1.37: 0.91-1.98). A supplementary sibling-matched Cox regression analysis likewise suggested there was no excess risk of MS in persons delivered by C-section (HR = 1.03; 0.63-1.69). CONCLUSIONS: Mode of delivery appears to be unimportant in relation to MS development in the offspring.
Authors: Jennifer S Graves; Tanuja Chitnis; Bianca Weinstock-Guttman; Jennifer Rubin; Aaron S Zelikovitch; Bardia Nourbakhsh; Timothy Simmons; Michael Waltz; T Charles Casper; Emmanuelle Waubant Journal: Pediatrics Date: 2017-04 Impact factor: 7.124
Authors: Emmanuelle Waubant; Robyn Lucas; Ellen Mowry; Jennifer Graves; Tomas Olsson; Lars Alfredsson; Annette Langer-Gould Journal: Ann Clin Transl Neurol Date: 2019-08-07 Impact factor: 4.511
Authors: Jorge E Chavarro; Nerea Martín-Calvo; Changzheng Yuan; Mariel Arvizu; Janet W Rich-Edwards; Karin B Michels; Qi Sun Journal: JAMA Netw Open Date: 2020-04-01