Clinical comparison of super high-flux HD and on-line HDF.

Super high-flux HD is quite popular in Japan. 90% of -dialysis patients are treated using dialyzers with a β2-microglobulin clearance of >50 ml/min. If the target is β2-microglobulin, HDF is not necessary. However, removal of uremic toxins with a higher molecular weight and stability of circulation status, which is expected of on-line HDF, would lead to better survival of the patients. Demonstration of the beneficial effect of on-line HDF on the outcome in patients is awaited.