Literature DB >> 234663

Glycosidases in human skin fibroblast cultures. Alpha-fucosidase, alpha-galactosidase, alpha-glucosidase, beta-mannosidase, and N-acetyl-alpha-glucosaminidase.

B Hultberg, S Sjöblad, P A Ockerman.   

Abstract

Five glycosidases, alpha-fucosidase, alpha-galactosidase, alpha-glucosidase, beta-mannosidase and N-acetyl-alpha-glucosaminidase were studied in human skin fibroblast cultures. The pH-dependency, kinetic properties of the enzymes and results of isoelectric focusing and ion exchange chromatography are presented. Techniques suitable for diagnosing inborn lysosomal diseases in skin fibroblast cultures are defined.

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Year:  1975        PMID： 234663

Source DB:  PubMed          Journal:  Acta Paediatr Scand        ISSN： 0001-656X


  7 in total

Review 1.  Basic findings and current developments in sphingolipidoses.

Authors:  H Pilz; R Heipertz; D Seidel
Journal:  Hum Genet       Date:  1979-03-12       Impact factor: 4.132

2.  Molecular forms and activities of glycosidases in cultures of amniotic-fluid cells.

Authors:  B Hultberg; J Lindsten; S Sjöblad
Journal:  Biochem J       Date:  1976-06-01       Impact factor: 3.857

3.  A novel fluorescent assay for T-synthase activity.

Authors:  Tongzhong Ju; Baoyun Xia; Rajindra P Aryal; Wenyi Wang; Yingchun Wang; Xiaokun Ding; Rongjuan Mi; Miao He; Richard D Cummings
Journal:  Glycobiology       Date:  2010-10-19       Impact factor: 4.313

4.  Fabry disease - current treatment and new drug development.

Authors:  Omid Motabar; Ellen Sidransky; Ehud Goldin; Wei Zheng
Journal:  Curr Chem Genomics       Date:  2010-07-23

5.  A new resorufin-based alpha-glucosidase assay for high-throughput screening.

Authors:  Omid Motabar; Zhen-Dan Shi; Ehud Goldin; Ke Liu; Noel Southall; Ellen Sidransky; Christopher P Austin; Gary L Griffiths; Wei Zheng
Journal:  Anal Biochem       Date:  2009-04-14       Impact factor: 3.365

6.  Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase.

Authors:  Zhen-Dan Shi; Omid Motabar; Ehud Goldin; Ke Liu; Noel Southall; Ellen Sidransky; Christopher P Austin; Gary L Griffiths; Wei Zheng
Journal:  Anal Bioanal Chem       Date:  2009-06-13       Impact factor: 4.142

7.  High throughput screening for inhibitors of alpha-galactosidase.

Authors:  Omid Motabar; Ke Liu; Noel Southall; Juan J Marugan; Ehud Goldin; Ellen Sidransky; Wei Zheng
Journal:  Curr Chem Genomics       Date:  2010-12-03
  7 in total

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