| Literature DB >> 23465926 |
Aleš Doliška1, Volker Ribitsch, Karin Stana Kleinschek, Simona Strnad.
Abstract
In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.Entities:
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Year: 2012 PMID： 23465926 DOI： 10.1016/j.carbpol.2012.02.075
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381