Literature DB >> 2346496

Characterization of a 5'-flanking region of the human liver/bone/kidney alkaline phosphatase gene: two kinds of mRNA from a single gene.

S Matsuura1, F Kishi, T Kajii.   

Abstract

We have cloned the human liver/bone/kidney alkaline phosphatase (ALPL) gene using a liver-type ALPL cDNA as a probe. The gene is divided into 12 exons, and is likely to exist as a single copy in haploid genome. As compared with the gene isolated using a bone-type ALPL cDNA (Weiss et al., J. Biol. Chem. 263, 12002-12010, 1988), another leader exon specific for the liver-type ALPL mRNA was assigned about 3.4 kb upstream from exon 2 and the alternative splicing in the first exon was indicated. RNA blot analysis showed that three species of mRNA of 2.5, 4.1 and 4.7 kilobases were detected in liver and developmentally regulated.

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Year:  1990        PMID： 2346496     DOI： 10.1016/0006-291x(90)91127-e

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Molecular evolution of the tissue-nonspecific alkaline phosphatase allows prediction and validation of missense mutations responsible for hypophosphatasia.

Authors:  Jérémie Silvent; Barbara Gasse; Etienne Mornet; Jean-Yves Sire
Journal:  J Biol Chem       Date:  2014-07-14       Impact factor: 5.157

2.  Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.

Authors:  T A Owen; R Bortell; S A Yocum; S L Smock; M Zhang; C Abate; V Shalhoub; N Aronin; K L Wright; A J van Wijnen
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  Human tissue non-specific alkaline phosphatases: sugar-moiety-induced enzymic and antigenic modulations and genetic aspects.

Authors:  O Nosjean; I Koyama; M Goseki; B Roux; T Komoda
Journal:  Biochem J       Date:  1997-01-15       Impact factor: 3.857

4.  Tandem duplication of alkaline phosphatase genes and polymorphism in the intergenic sequence in Bombyx mori.

Authors:  M Itoh; T Inoue; Y Kanamori; S Nishida; M Yamaguchi
Journal:  Mol Genet Genomics       Date:  2003-09-24       Impact factor: 3.291

5.  Retinoic acid and cyclic AMP synergistically induce the expression of liver/bone/kidney-type alkaline phosphatase gene in L929 fibroblastic cells.

Authors:  M Giannì; M Terao; S Sozzani; E Garattini
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857

Review 6.  Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease.

Authors:  Álvaro Sebastián-Serrano; Laura de Diego-García; Carlos Martínez-Frailes; Jesús Ávila; Herbert Zimmermann; José Luis Millán; María Teresa Miras-Portugal; Miguel Díaz-Hernández
Journal:  Comput Struct Biotechnol J       Date:  2014-12-15       Impact factor: 7.271

Review 7.  Pathophysiology of hypophosphatasia and the potential role of asfotase alfa.

Authors:  Hideo Orimo
Journal:  Ther Clin Risk Manag       Date:  2016-05-17       Impact factor: 2.423

Review 8.  Tissue-Nonspecific Alkaline Phosphatase in Central Nervous System Health and Disease: A Focus on Brain Microvascular Endothelial Cells.

Authors:  Divine C Nwafor; Allison L Brichacek; Ahsan Ali; Candice M Brown
Journal:  Int J Mol Sci       Date:  2021-05-17       Impact factor: 5.923

9.  TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties.

Authors:  Barbara Deracinois; Sophie Duban-Deweer; Gwënaël Pottiez; Roméo Cecchelli; Yannis Karamanos; Christophe Flahaut
Journal:  PLoS One       Date:  2012-10-31       Impact factor: 3.240

Review 10.  Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells.

Authors:  David Estève; Jean Galitzky; Anne Bouloumié; Caroline Fonta; René Buchet; David Magne
Journal:  Stem Cells Int       Date:  2015-12-29       Impact factor: 5.443
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