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Literature DB >> 23464668

Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation.

Xin Gao¹, Sang Kook Woo, Michael J Krische.

Abstract

The 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20 total steps. Two different methods for alcohol CH-crotylation via transfer hydrogenation are deployed for the first time in target-oriented synthesis. Enyne metathesis is used to form the 14-membered ring. The present approach represents the most concise construction of any erythronolide reported, to date.

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 23464668 PMCID： PMC3625983 DOI： 10.1021/ja4008722

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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