Literature DB >> 23464518

Potential of targeting TGF-β for organ transplant patients.

Makio Iwashima1, Robert Love.   

Abstract

TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF- β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.

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Year:  2013        PMID： 23464518      PMCID： PMC4429753          DOI： 10.4155/fmc.12.215

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  80 in total

Review 1.  IL-9 and lung fibrosis: a Th2 good guy?

Authors:  G W Hoyle; A R Brody
Journal:  Am J Respir Cell Mol Biol       Date:  2001-04       Impact factor: 6.914

2.  Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo.

Authors:  Marc A Gavin; Sally R Clarke; Ella Negrou; Alena Gallegos; Alexander Rudensky
Journal:  Nat Immunol       Date:  2001-12-10       Impact factor: 25.606

Review 3.  Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria.

Authors:  Marc Estenne; Janet R Maurer; Annette Boehler; James J Egan; Adaani Frost; Marshall Hertz; George B Mallory; Gregory I Snell; Samuel Yousem
Journal:  J Heart Lung Transplant       Date:  2002-03       Impact factor: 10.247

4.  T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection.

Authors:  Hillary K Rolls; Koji Kishimoto; Victor M Dong; Ben M-W Illigens; Masayuki Sho; Mohamed H Sayegh; Gilles Benichou; Eugenia V Fedoseyeva
Journal:  Transplantation       Date:  2002-10-15       Impact factor: 4.939

Review 5.  Making sense of latent TGFbeta activation.

Authors:  Justin P Annes; John S Munger; Daniel B Rifkin
Journal:  J Cell Sci       Date:  2003-01-15       Impact factor: 5.285

6.  The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

Authors:  C L Bennett; J Christie; F Ramsdell; M E Brunkow; P J Ferguson; L Whitesell; T E Kelly; F T Saulsbury; P F Chance; H D Ochs
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

7.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Authors:  M E Brunkow; E W Jeffery; K A Hjerrild; B Paeper; L B Clark; S A Yasayko; J E Wilkinson; D Galas; S F Ziegler; F Ramsdell
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

8.  JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.

Authors:  T A Chatila; F Blaeser; N Ho; H M Lederman; C Voulgaropoulos; C Helms; A M Bowcock
Journal:  J Clin Invest       Date:  2000-12       Impact factor: 14.808

Review 9.  Risk factors for bronchiolitis obliterans: a systematic review of recent publications.

Authors:  Linda D Sharples; Keith McNeil; Susan Stewart; John Wallwork
Journal:  J Heart Lung Transplant       Date:  2002-02       Impact factor: 10.247

10.  X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.

Authors:  R S Wildin; F Ramsdell; J Peake; F Faravelli; J L Casanova; N Buist; E Levy-Lahad; M Mazzella; O Goulet; L Perroni; F D Bricarelli; G Byrne; M McEuen; S Proll; M Appleby; M E Brunkow
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330
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  2 in total

1.  Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity.

Authors:  Wen Chean Lim; Michael Olding; Eugene Healy; Timothy M Millar
Journal:  Front Immunol       Date:  2018-03-23       Impact factor: 7.561

Review 2.  Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation.

Authors:  Esmaeil Mortaz; Saeede Amani; Sharon Mumby; Ian M Adcock; Mehrnaz Movassaghi; Jelle Folkerts; Johan Garssen; Gert Folkerts
Journal:  J Immunol Res       Date:  2018-10-30       Impact factor: 4.818
  2 in total

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