Literature DB >> 23463290

The influence of botulinum toxin A injections into the calf muscles on genu recurvatum in children with cerebral palsy.

Matthias C M Klotz1, Sebastian I Wolf, Daniel Heitzmann, Simone Gantz, Frank Braatz, Thomas Dreher.   

Abstract

BACKGROUND: With cerebral palsy (CP), an equinus deformity may lead to genu recurvatum. Botulinum toxin A (BtA) injection into the calf muscles is a well-accepted treatment for dynamic equinus deformity. QUESTIONS/PURPOSES: The purpose of this study was to determine whether BtA injections into the calf muscles to decrease equinus would decrease coexisting genu recurvatum in children with diplegic CP.
METHODS: In a retrospective study, 13 children (mean age, 5 years) with spastic diplegic CP showing equinus and coexisting primary genu recurvatum, who were treated with BtA injections into the calf muscles, were included. Evaluations were done before and 6 and 18 weeks after intervention using three-dimensional gait analysis and clinical examinations according to a standardized protocol. Basic statistical analyses (power analysis, ANOVA) were performed to compare genu recurvatum before treatment and at 6 and 18 weeks after injection with BtA.
RESULTS: During stance phase, maximum ankle dorsiflexion was increased substantially from -3.0° ± 14.3° before to 6.2° ± 14.2° 6 weeks after the injections. Despite this, with the numbers available, the amount of recurvatum in stance did not improve with treatment at either 6 or 18 weeks. There was significant improvement of knee hyperextension during stance phase of 6.2° between baseline and 18 weeks after BtA injection, but a genu recurvatum was still present in most patients.
CONCLUSIONS: Despite improvement of ankle dorsiflexion after injection with BtA, genu recurvatum did not show relevant improvement at 6 or 18 weeks after injection with the numbers available. Because knee hyperextension remained in most patients, other factors leading to genu recurvatum should be taken into consideration. In addition, a botulinum toxin-induced weakness of the gastrocnemius may explain why recurvatum gait was not significantly reduced. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Year:  2013        PMID: 23463290      PMCID: PMC3676585          DOI: 10.1007/s11999-013-2897-7

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN: 0009-921X            Impact factor:   4.176


  33 in total

1.  Contributions of the individual ankle plantar flexors to support, forward progression and swing initiation during walking.

Authors:  R R Neptune; S A Kautz; F E Zajac
Journal:  J Biomech       Date:  2001-11       Impact factor: 2.712

2.  Sagittal gait patterns in spastic diplegia.

Authors:  J M Rodda; H K Graham; L Carson; M P Galea; R Wolfe
Journal:  J Bone Joint Surg Br       Date:  2004-03

3.  Ankle and knee coupling in patients with spastic diplegia: effects of gastrocnemius-soleus lengthening.

Authors:  Adrian Baddar; Kevin Granata; Diane L Damiano; David V Carmines; John S Blanco; Mark F Abel
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4.  Repeated botulinum toxin A injections in the treatment of spastic equinus foot.

Authors:  Dimitrios Metaxiotis; Andrea Siebel; Leonhard Doederlein
Journal:  Clin Orthop Relat Res       Date:  2002-01       Impact factor: 4.176

Review 5.  Recommendations for the use of botulinum toxin type A in the management of cerebral palsy.

Authors:  H K Graham; K R Aoki; I Autti-Rämö; R N Boyd; M R Delgado; D J Gaebler-Spira; M E Gormley; B M Guyer; F Heinen; A F Holton; D Matthews; G Molenaers; F Motta; P J García Ruiz; J Wissel
Journal:  Gait Posture       Date:  2000-02       Impact factor: 2.840

Review 6.  Botulinum toxin type A in the management of equinus in children with cerebral palsy: an evidence-based economic evaluation.

Authors:  J Houltram; I Noble; R N Boyd; I Corry; P Flett; H K Graham
Journal:  Eur J Neurol       Date:  2001-11       Impact factor: 6.089

7.  Effects of botulinum toxin A in ambulant adults with spastic cerebral palsy: a randomized double-blind placebo controlled-trial.

Authors:  Grethe Maanum; Reidun Jahnsen; Johan K Stanghelle; Leiv Sandvik; Anne Keller
Journal:  J Rehabil Med       Date:  2011-03       Impact factor: 2.912

8.  Double-blind comparison study of two doses of botulinum toxin A injected into calf muscles in children with hemiplegic cerebral palsy.

Authors:  Frances Polak; Richard Morton; Christopher Ward; W Angus Wallace; Leonard Doderlein; Andrea Siebel
Journal:  Dev Med Child Neurol       Date:  2002-08       Impact factor: 5.449

9.  The vulpius procedure for correction of equinus deformity in patients with hemiplegia.

Authors:  Suichiro Takahashi; Arjun Shrestha
Journal:  J Bone Joint Surg Br       Date:  2002-09

10.  Change of dynamic gastrocnemius and soleus muscle length after block of spastic calf muscle in cerebral palsy.

Authors:  Moon Suk Bang; Sun Gun Chung; Sang Beom Kim; Sang-Jun Kim
Journal:  Am J Phys Med Rehabil       Date:  2002-10       Impact factor: 2.159

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  4 in total

1.  Calf lengthening may improve knee recurvatum in specific children with spastic diplegic cerebral palsy.

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Review 2.  Literature Review and Comparison of Two Statistical Methods to Evaluate the Effect of Botulinum Toxin Treatment on Gait in Children with Cerebral Palsy.

Authors:  Angela Nieuwenhuys; Eirini Papageorgiou; Todd Pataky; Tinne De Laet; Guy Molenaers; Kaat Desloovere
Journal:  PLoS One       Date:  2016-03-31       Impact factor: 3.240

3.  Botulinum Toxin Type A Injection for Spastic Equinovarus Foot in Children with Spastic Cerebral Palsy: Effects on Gait and Foot Pressure Distribution.

Authors:  Ja Young Choi; Soojin Jung; Dong Wook Rha; Eun Sook Park
Journal:  Yonsei Med J       Date:  2016-03       Impact factor: 2.759

4.  A New Method for Postural Misalignment of a 6-Year-Old Girl With Cerebral Palsy: A Case Report.

Authors:  Ying Hou; Huitian Zheng; Jinping Li; Shujia Wang; Dongmei Zhang; Tong Tang; Mindan Xu; Hong Zhou
Journal:  Arch Rehabil Res Clin Transl       Date:  2021-02-23
  4 in total

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