OBJECTIVE: To use familial risk analysis to examine the association between attention-deficit hyperactivity disorder (ADHD) and nicotine dependence (ND). METHOD: Subjects were children with (n = 257) and without (n = 229) ADHD of both sexes ascertained from pediatric and psychiatric referral sources and their first-degree relatives (N = 1627). RESULTS: ND in probands increased the risk for ND in relatives irrespective of ADHD status. There was no evidence of cosegregation or assortative mating between these disorders. Patterns of familial risk analysis suggest that the association between ADHD and ND is most consistent with the hypothesis of independent transmission of these disorders. CONCLUSIONS: These findings may have important implications for the identification of a subgroup of children with ADHD at high risk for ND based on parental history of ND.
OBJECTIVE: To use familial risk analysis to examine the association between attention-deficit hyperactivity disorder (ADHD) and nicotine dependence (ND). METHOD: Subjects were children with (n = 257) and without (n = 229) ADHD of both sexes ascertained from pediatric and psychiatric referral sources and their first-degree relatives (N = 1627). RESULTS:ND in probands increased the risk for ND in relatives irrespective of ADHD status. There was no evidence of cosegregation or assortative mating between these disorders. Patterns of familial risk analysis suggest that the association between ADHD and ND is most consistent with the hypothesis of independent transmission of these disorders. CONCLUSIONS: These findings may have important implications for the identification of a subgroup of children with ADHD at high risk for ND based on parental history of ND.
Authors: Gary L Humfleet; Judith J Prochaska; Matilda Mengis; Jennifer Cullen; Ricardo Muñoz; Victor Reus; Sharon M Hall Journal: Nicotine Tob Res Date: 2005-06 Impact factor: 4.244
Authors: J Biederman; S Faraone; S Milberger; J Guite; E Mick; L Chen; D Mennin; A Marrs; C Ouellette; P Moore; T Spencer; D Norman; T Wilens; I Kraus; J Perrin Journal: Arch Gen Psychiatry Date: 1996-05
Authors: J Biederman; S V Faraone; E Mick; S Williamson; T E Wilens; T J Spencer; W Weber; J Jetton; I Kraus; J Pert; B Zallen Journal: J Am Acad Child Adolesc Psychiatry Date: 1999-08 Impact factor: 8.829
Authors: J Biederman; S V Faraone; W Weber; R L Russell; M Rater; K S Park Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-12 Impact factor: 8.829
Authors: Cynthia S Pomerleau; Karen K Downey; Sandy M Snedecor; Ann M Mehringer; Judith L Marks; Ovide F Pomerleau Journal: Addict Behav Date: 2003-08 Impact factor: 3.913
Authors: Betsy Busch; Joseph Biederman; Louise Glassner Cohen; Julie M Sayer; Michael C Monuteaux; Eric Mick; Barry Zallen; Stephen V Faraone Journal: Psychiatr Serv Date: 2002-09 Impact factor: 3.084