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Literature DB >> 23461762

NHC-Cu-catalyzed protoboration of monosubstituted allenes. Ligand-controlled site selectivity, application to synthesis and mechanism.

Fanke Meng¹, Byunghyuck Jung, Fredrik Haeffner, Amir H Hoveyda.

Abstract

Two types of NHC-Cu complexes catalyze protoborations of terminal allenes to afford valuable 1,1- or trisubstituted vinylboron species with high site selectivity and stereoselectivity. The scope of the method, application to natural product synthesis, and mechanistic basis for the observed selectivity trends are presented.

Entities: Chemical Disease Gene

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Year: 2013 PMID： 23461762 PMCID： PMC3625862 DOI： 10.1021/ol4004178

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

12 in total

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