BACKGROUND: The onset of sarcoidosis is thought to be seasonal, particularly Lofgren's syndrome. However, there are conflicting data on seasonality by country and by radiographic stage. OBJECTIVE: The objective of this study was to determine if there is seasonality of the diagnosis of sarcoidosis in outpatients in the United States. METHODS AND RESULTS: Using time series methods, we performed a retrospective analysis of 3791 incident cases of sarcoidosis in the Veteran's Health Administration national outpatient claims database (2000-2007). We did not find overall seasonality in the occurrence of new sarcoidosis in United States Veterans (p = 0.9860), even after we subdivided the United States by northern (p = 0.6824) and southern regions (p = 0.4588). CONCLUSION: The lack of seasonality in this study indicates that season is not a dominant factor in complex gene-environment-host interaction that precedes presentation of new sarcoidosis cases in the United States Veteran population.
BACKGROUND: The onset of sarcoidosis is thought to be seasonal, particularly Lofgren's syndrome. However, there are conflicting data on seasonality by country and by radiographic stage. OBJECTIVE: The objective of this study was to determine if there is seasonality of the diagnosis of sarcoidosis in outpatients in the United States. METHODS AND RESULTS: Using time series methods, we performed a retrospective analysis of 3791 incident cases of sarcoidosis in the Veteran's Health Administration national outpatient claims database (2000-2007). We did not find overall seasonality in the occurrence of new sarcoidosis in United States Veterans (p = 0.9860), even after we subdivided the United States by northern (p = 0.6824) and southern regions (p = 0.4588). CONCLUSION: The lack of seasonality in this study indicates that season is not a dominant factor in complex gene-environment-host interaction that precedes presentation of new sarcoidosis cases in the United States Veteran population.
Authors: R P Baughman; A S Teirstein; M A Judson; M D Rossman; H Yeager; E A Bresnitz; L DePalo; G Hunninghake; M C Iannuzzi; C J Johns; G McLennan; D R Moller; L S Newman; D L Rabin; C Rose; B Rybicki; S E Weinberger; M L Terrin; G L Knatterud; R Cherniak Journal: Am J Respir Crit Care Med Date: 2001-11-15 Impact factor: 21.405
Authors: Edward D Gorham; Cedric F Garland; Frank C Garland; Kevin Kaiser; William D Travis; Jose A Centeno Journal: Chest Date: 2004-11 Impact factor: 9.410