Literature DB >> 23460740

Novel function of Trim44 promotes an antiviral response by stabilizing VISA.

Bo Yang1, Jie Wang, Yanming Wang, Haiyan Zhou, Xiaodong Wu, Zhigang Tian, Bing Sun.   

Abstract

Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.

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Year:  2013        PMID： 23460740     DOI： 10.4049/jimmunol.1202507

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  35 in total

1.  Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Authors:  Zhifang Cao; Kara L Conway; Robert J Heath; Jason S Rush; Elizaveta S Leshchiner; Zaida G Ramirez-Ortiz; Natalia B Nedelsky; Hailiang Huang; Aylwin Ng; Agnès Gardet; Shih-Chin Cheng; Alykhan F Shamji; John D Rioux; Cisca Wijmenga; Mihai G Netea; Terry K Means; Mark J Daly; Ramnik J Xavier
Journal:  Immunity       Date:  2015-10-20       Impact factor: 31.745

Review 2.  TRIM Proteins and Their Roles in Antiviral Host Defenses.

Authors:  Michiel van Gent; Konstantin M J Sparrer; Michaela U Gack
Journal:  Annu Rev Virol       Date:  2018-06-27       Impact factor: 10.431

Review 3.  Ubiquitination in the antiviral immune response.

Authors:  Meredith E Davis; Michaela U Gack
Journal:  Virology       Date:  2015-03-07       Impact factor: 3.616

4.  Trim44 facilitates the migration and invasion of human lung cancer cells via the NF-κB signaling pathway.

Authors:  Qingquan Luo; Hao Lin; Xiangyun Ye; Jia Huang; Shun Lu; Lin Xu
Journal:  Int J Clin Oncol       Date:  2014-10-28       Impact factor: 3.402

Review 5.  TRIMs: selective recruitment at different steps of the NF-κB pathway-determinant of activation or resolution of inflammation.

Authors:  Milton Roy; Rajesh Singh
Journal:  Cell Mol Life Sci       Date:  2021-07-20       Impact factor: 9.261

Review 6.  TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.

Authors:  Ricardo Rajsbaum; Adolfo García-Sastre; Gijs A Versteeg
Journal:  J Mol Biol       Date:  2013-12-12       Impact factor: 5.469

7.  TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway.

Authors:  Xia Zhou; Yadong Yang; Pengcheng Ma; Na Wang; Dong Yang; Qiu Tu; Bin Sun; Tingxiu Xiang; Xudong Zhao; Zongliu Hou; Xiangdong Fang
Journal:  J Neurooncol       Date:  2019-10-11       Impact factor: 4.130

8.  Tripartite motif proteins: an emerging antiviral protein family.

Authors:  Girish Patil; Shitao Li
Journal:  Future Virol       Date:  2019-01-21       Impact factor: 1.831

9.  TRIM13 is a negative regulator of MDA5-mediated type I interferon production.

Authors:  Kavitha Narayan; Lisa Waggoner; Serena T Pham; Gabriel L Hendricks; Stephen N Waggoner; Joseph Conlon; Jennifer P Wang; Katherine A Fitzgerald; Joonsoo Kang
Journal:  J Virol       Date:  2014-07-09       Impact factor: 5.103

10.  TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.

Authors:  Binbin Xue; Huiyi Li; Mengmeng Guo; Jingjing Wang; Yan Xu; Xuan Zou; Rilin Deng; Guangdi Li; Haizhen Zhu
Journal:  J Virol       Date:  2018-06-29       Impact factor: 5.103
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