Literature DB >> 23460127

Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling.

Kurt Hoogewijs1, Dieter Buyst, Johan M Winne, José C Martins, Annemieke Madder.   

Abstract

A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes.

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Year:  2013        PMID: 23460127     DOI: 10.1039/c3cc40588e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Triazolinediones enable ultrafast and reversible click chemistry for the design of dynamic polymer systems.

Authors:  Stijn Billiet; Kevin De Bruycker; Frank Driessen; Hannelore Goossens; Veronique Van Speybroeck; Johan M Winne; Filip E Du Prez
Journal:  Nat Chem       Date:  2014-08-11       Impact factor: 24.427

  1 in total

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