OBJECTIVE: The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS). MATERIAL/ METHODS: We evaluated 80 elderly individuals who were distributed into three groups: MetS, abdominal obesity (AbObes) and Control, according to ATPIII criteria. Interleukin-6 (IL-6) serum concentration was measured at 0, 2, 4 and 6 hours after the ingestion of a physiological meal without an overload of fat. RESULTS: Serum IL-6 increased 6 hours after the meal in all of the groups (P<0.001). Comparing the groups, there was no difference in the area under the curve (AUC) of IL-6 in the postprandial state. There was a correlation between the 6-hour changes in the concentrations of IL-6 and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.25, P<0.05). CONCLUSION: In this study, differences in abdominal circumference (AC) have not determined a different behavior of IL-6 in the postprandial state, despite the correlation between AC and IL-6. However, we found that, in the elderly, there is a rise in serum IL-6 at 6 hours.
OBJECTIVE: The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS). MATERIAL/ METHODS: We evaluated 80 elderly individuals who were distributed into three groups: MetS, abdominal obesity (AbObes) and Control, according to ATPIII criteria. Interleukin-6 (IL-6) serum concentration was measured at 0, 2, 4 and 6 hours after the ingestion of a physiological meal without an overload of fat. RESULTS: Serum IL-6 increased 6 hours after the meal in all of the groups (P<0.001). Comparing the groups, there was no difference in the area under the curve (AUC) of IL-6 in the postprandial state. There was a correlation between the 6-hour changes in the concentrations of IL-6 and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.25, P<0.05). CONCLUSION: In this study, differences in abdominal circumference (AC) have not determined a different behavior of IL-6 in the postprandial state, despite the correlation between AC and IL-6. However, we found that, in the elderly, there is a rise in serum IL-6 at 6 hours.
Authors: Elham M Youssef-Elabd; Kirsty C McGee; Gyanendra Tripathi; Nasser Aldaghri; Mohga S Abdalla; Hayat M Sharada; Esmat Ashour; Ashraf I Amin; Antonio Ceriello; Joseph P O'Hare; Sudhesh Kumar; Philip G McTernan; Alison L Harte Journal: J Nutr Biochem Date: 2011-03-16 Impact factor: 6.048
Authors: Genovefa D Kolovou; Katherine K Anagnostopoulou; Antonis N Pavlidis; Klelia D Salpea; Stella A Iraklianou; Konstantinos Tsarpalis; Dimitris S Damaskos; Athanasios Manolis; Dennis V Cokkinos Journal: Lipids Health Dis Date: 2005-09-30 Impact factor: 3.876