N Bauer1, A Moritz. 1. Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus-Liebig University Giessen, Giessen, Germany.
Abstract
OBJECTIVE: To prospectively assess (2008 to 2009) all phases of coagulation including thromboelastography in dogs with thrombosis to determine if thrombosis is associated with hypercoagulable states. METHODS: Coagulation reaction in dogs with thrombosis (n = 7) diagnosed by diagnostic imaging or histopathology was compared with 56 control dogs. Dogs pretreated with antiplatelet and anticoagulation drugs were excluded. Thromboelastographic G-values >10 · 3 Kdyn/cm(2) were used to define a hypercoagulable state. RESULTS: Compared with the controls, there was a significantly higher mean platelet component indicating lower platelet activation status (17 · 99 ±1 · 36 versus 20 · 48 ±2 · 04 g/dL, P = 0 · 0004), increased thromboelastographic G-value (6 · 4 ±1 · 6 versus 13 · 1 ±6 · 2 Kdyn/cm(2) , P = 0 · 0029), activated partial thromboplastin time, fibrinogen, D-dimers (all: P < 0 · 0001) as well as decreased antithrombin (P = 0 · 0049), factor VIII (P < 0 · 0001), protein C (P < 0 · 0001), protein S (P = 0 · 0373) and activated protein C-ratio (P = 0 · 0013). On the basis of thromboelastographic G-value, three of six thromboelastographic tracings were classified as normocoagulable and three as hypercoagulable. CLINICAL RELEVANCE: In dogs with thrombosis, both normo- and hypercoagulable states are present and activated protein C resistance is common.
OBJECTIVE: To prospectively assess (2008 to 2009) all phases of coagulation including thromboelastography in dogs with thrombosis to determine if thrombosis is associated with hypercoagulable states. METHODS: Coagulation reaction in dogs with thrombosis (n = 7) diagnosed by diagnostic imaging or histopathology was compared with 56 control dogs. Dogs pretreated with antiplatelet and anticoagulation drugs were excluded. Thromboelastographic G-values >10 · 3 Kdyn/cm(2) were used to define a hypercoagulable state. RESULTS: Compared with the controls, there was a significantly higher mean platelet component indicating lower platelet activation status (17 · 99 ±1 · 36 versus 20 · 48 ±2 · 04 g/dL, P = 0 · 0004), increased thromboelastographic G-value (6 · 4 ±1 · 6 versus 13 · 1 ±6 · 2 Kdyn/cm(2) , P = 0 · 0029), activated partial thromboplastin time, fibrinogen, D-dimers (all: P < 0 · 0001) as well as decreased antithrombin (P = 0 · 0049), factor VIII (P < 0 · 0001), protein C (P < 0 · 0001), protein S (P = 0 · 0373) and activated protein C-ratio (P = 0 · 0013). On the basis of thromboelastographic G-value, three of six thromboelastographic tracings were classified as normocoagulable and three as hypercoagulable. CLINICAL RELEVANCE: In dogs with thrombosis, both normo- and hypercoagulable states are present and activated protein C resistance is common.
Authors: James W Swann; Oliver A Garden; Claire L Fellman; Barbara Glanemann; Robert Goggs; Dana N LeVine; Andrew J Mackin; Nathaniel T Whitley Journal: J Vet Intern Med Date: 2019-03-07 Impact factor: 3.333
Authors: Armelle deLaforcade; Lenore Bacek; Marie-Claude Blais; Corrin Boyd; Benjamin M Brainard; Daniel L Chan; Stefano Cortellini; Robert Goggs; Guillaume L Hoareau; Amy Koenigshof; Ron Li; Alex Lynch; Alan Ralph; Elizabeth Rozanski; Claire R Sharp Journal: J Vet Emerg Crit Care (San Antonio) Date: 2022-05-02