Literature DB >> 2345864

Role of zinc in interleukin 2 (IL-2)-mediated T-cell activation.

Y Tanaka1, S Shiozawa, I Morimoto, T Fujita.   

Abstract

In a serum-free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (IL-2), and also the in vitro production of IL-2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti-IL-2 antibodies, it was completely inhibited by anti-IL-2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high-affinity receptors for IL-2 on lymphocytes. The results indicated that zinc may be essentially required for IL-2-mediated T-cell activation.

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Year:  1990        PMID： 2345864     DOI： 10.1111/j.1365-3083.1990.tb02805.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  10 in total

1.  Improvement of the lymphoproliferative immune response and apoptosis inhibition upon in vitro treatment with zinc of peripheral blood mononuclear cells (PBMC) from HIV+ individuals.

Authors:  I Neves; A L Bertho; V G Veloso; D V Nascimento; D L Campos-Mello; M G Morgado
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

Review 2.  The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent.

Authors:  Bin Bao; Archana Thakur; Yiwei Li; Aamir Ahmad; Asfar S Azmi; Sanjeev Banerjee; Dejuan Kong; Shadan Ali; Lawrence G Lum; Fazlul H Sarkar
Journal:  Biochim Biophys Acta       Date:  2011-11-29

3.  Gamma interferon is produced by human natural killer cells but not T cells during Staphylococcus aureus stimulation.

Authors:  R Yoshihara; S Shiozawa; T Fujita; K Chihara
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

4.  Zinc supplementation stimulates tetanus antibody formation and soluble interleukin-2 receptor levels in chronic hemodialysis patients.

Authors:  W Holtkamp; H P Brodersen; T Stollberg; J Thiery; C Falkner
Journal:  Clin Investig       Date:  1993-07

5.  Effect of zinc on humoral and cell-mediated immunity of broilers vaccinated against coccidiosis.

Authors:  Sobhan Sajadifar; Hadi Miranzadeh; Milad Moazeni
Journal:  Iran J Parasitol       Date:  2013-07       Impact factor: 1.012

Review 6.  Roles of Zinc Signaling in the Immune System.

Authors:  Shintaro Hojyo; Toshiyuki Fukada
Journal:  J Immunol Res       Date:  2016-10-31       Impact factor: 4.818

7.  Effect of zinc addition on the immune response and production performance of broilers: a meta-analysis.

Authors:  Cecep Hidayat; Anuraga Jayanegara; Elizabeth Wina
Journal:  Asian-Australas J Anim Sci       Date:  2019-05-28       Impact factor: 2.509

8.  Correlation between serum albumin and serum zinc in malignant lymphoma.

Authors:  Misaki Morisaku; Kaori Ito; Anna Ogiso; Misa Imai; Yoshiko Hiraoka; Miho Zennami; Masahiro Tsuge; Maiko Mori; Seira Toyosato; Hidezo Matsuda; Yosuke Ando; Masutaka Tokuda; Akihiro Tomita; Shigeki Yamada
Journal:  Fujita Med J       Date:  2021-08-20

9.  Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma.

Authors:  E Mocchegiani; A Ciavattini; L Santarelli; A Tibaldi; M Muzzioli; P Bonazzi; R Giacconi; N Fabris; G G Garzetti
Journal:  Br J Cancer       Date:  1999-01       Impact factor: 7.640

Review 10.  Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era.

Authors:  Leila Abdelhamid; Xin M Luo
Journal:  Front Immunol       Date:  2022-01-05       Impact factor: 7.561
  10 in total

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