Alison M Stuebe1, Alison Wise2, Thutrang Nguyen3, Amy Herring2, Kari E North4, Anna Maria Siega-Riz4. 1. Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina. 2. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 3. Division of Genetics and Endocrinology, Children's Hospital of Boston, Harvard Medical School, Boston, Massachusetts. 4. Department of Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Abstract
OBJECTIVE: To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM). STUDY DESIGN: We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations. RESULTS: GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele. CONCLUSION: We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM). STUDY DESIGN: We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations. RESULTS: GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2rs7901695, MTNR1Brs10830963 and GCKRrs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1rs864745 T allele. CONCLUSION: We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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