Literature DB >> 23454382

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

Yoon Sun Cho1, Hye Jin Jung, Seung Hyeok Seok, Alexander Y Payumo, James K Chen, Ho Jeong Kwon.   

Abstract

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23454382      PMCID： PMC3691074          DOI： 10.1016/j.bbrc.2013.02.082

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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