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Literature DB >> 23454209

Regulated unfolding of proteins in signaling.

Abstract

The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Proteins

Year: 2013 PMID： 23454209 PMCID： PMC4898947 DOI： 10.1016/j.febslet.2013.02.024

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

95 in total

1. Disruption of the LOV-Jalpha helix interaction activates phototropin kinase activity.

Authors: Shannon M Harper; John M Christie; Kevin H Gardner
Journal: Biochemistry Date: 2004-12-28 Impact factor: 3.162

2. Cell biology. The importance of being unfolded.

Authors: K W Plaxco; M Gross
Journal: Nature Date: 1997-04-17 Impact factor: 49.962

3. Structural characterization of two alternate conformations in a calbindin D₉k-based molecular switch.

Authors: Margaret M Stratton; Sebastian McClendon; David Eliezer; Stewart N Loh
Journal: Biochemistry Date: 2011-06-01 Impact factor: 3.162

Review 4. Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.

Authors: Diana M Mitrea; Mi-Kyung Yoon; Li Ou; Richard W Kriwacki
Journal: Biol Chem Date: 2012-04 Impact factor: 3.915

5. Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase.

Authors: Martin Gustavsson; Nathaniel J Traaseth; Christine B Karim; Elizabeth L Lockamy; David D Thomas; Gianluigi Veglia
Journal: J Mol Biol Date: 2011-03-17 Impact factor: 5.469

6. New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate.

Authors: Richard D S Dixon; Yiwen Chen; Feng Ding; Sagar D Khare; Kirk C Prutzman; Michael D Schaller; Sharon L Campbell; Nikolay V Dokholyan
Journal: Structure Date: 2004-12 Impact factor: 5.006

7. Structural basis of a phototropin light switch.

Authors: Shannon M Harper; Lori C Neil; Kevin H Gardner
Journal: Science Date: 2003-09-12 Impact factor: 47.728

8. Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace.

Authors: Thomas J Jönsson; Lynnette C Johnson; W Todd Lowther
Journal: Nature Date: 2008-01-03 Impact factor: 49.962

9. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Authors: J J Ward; J S Sodhi; L J McGuffin; B F Buxton; D T Jones
Journal: J Mol Biol Date: 2004-03-26 Impact factor: 5.469

10. Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome.

Authors: Charles A Galea; Anthony A High; John C Obenauer; Ashutosh Mishra; Cheon-Gil Park; Marco Punta; Avner Schlessinger; Jing Ma; Burkhard Rost; Clive A Slaughter; Richard W Kriwacki
Journal: J Proteome Res Date: 2009-01 Impact factor: 4.466

34 in total

1. Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL.

Authors: Xiaorong Liu; Alex Beugelsdijk; Jianhan Chen
Journal: Biophys J Date: 2015-09-01 Impact factor: 4.033

2. HyRes: a coarse-grained model for multi-scale enhanced sampling of disordered protein conformations.

Authors: Xiaorong Liu; Jianhan Chen
Journal: Phys Chem Chem Phys Date: 2017-12-13 Impact factor: 3.676

3. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

Authors: Alaji Bah; Robert M Vernon; Zeba Siddiqui; Mickaël Krzeminski; Ranjith Muhandiram; Charlie Zhao; Nahum Sonenberg; Lewis E Kay; Julie D Forman-Kay
Journal: Nature Date: 2014-12-22 Impact factor: 49.962

Review 4. Advantages of proteins being disordered.

Authors: Zhirong Liu; Yongqi Huang
Journal: Protein Sci Date: 2014-03-17 Impact factor: 6.725

Review 5. Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.

Authors: Veronika Csizmok; Ariele Viacava Follis; Richard W Kriwacki; Julie D Forman-Kay
Journal: Chem Rev Date: 2016-02-29 Impact factor: 60.622

6. Thermodynamics of Conformational Transitions in a Disordered Protein Backbone Model.

Authors: Justin A Drake; B Montgomery Pettitt
Journal: Biophys J Date: 2018-06-19 Impact factor: 4.033

Review 7. Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications.

Authors: Alaji Bah; Julie D Forman-Kay
Journal: J Biol Chem Date: 2016-02-05 Impact factor: 5.157

Review 8. Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins.

Authors: Vladimir N Uversky
Journal: J Biol Chem Date: 2016-02-05 Impact factor: 5.157

9. Combined probes of X-ray scattering and optical spectroscopy reveal how global conformational change is temporally and spatially linked to local structural perturbation in photoactive yellow protein.

Authors: Tae Wu Kim; Cheolhee Yang; Youngmin Kim; Jong Goo Kim; Jeongho Kim; Yang Ouk Jung; Sunhong Jun; Sang Jin Lee; Sungjun Park; Irina Kosheleva; Robert Henning; Jasper J van Thor; Hyotcherl Ihee
Journal: Phys Chem Chem Phys Date: 2016-04-07 Impact factor: 3.676

10. Enhanced Sampling of Intrinsic Structural Heterogeneity of the BH3-Only Protein Binding Interface of Bcl-xL.

Authors: Xiaorong Liu; Zhiguang Jia; Jianhan Chen
Journal: J Phys Chem B Date: 2017-09-27 Impact factor: 2.991