OBJECTIVES: The objective of this study was to assess the short-term effect of plasmonic photothermal therapy (PPTT) on induced hamster buccal pouch (HBP) carcinoma. STUDY DESIGN: Seventy-six Syrian golden male hamsters were used. The induced HBP carcinomas were directly injected with ∼30 nm gold nanospheres followed by 15 min laser exposure (PPTT). RESULTS: PPTT caused rapid growth cessation and dramatic decrease in tumor sizes after 4 weeks of treatment (P < .05) compared to controls. Microscopic and immunohistochemical examination of the tumor biopsies revealed significant differences in the cellular apoptotic index (AI) value and proliferating cell nuclear antigen (PCNA) immunoexpression in PPTT-treated tumor tissue sections compared to controls (P < .05). Survival probability of the treated animals was increased compared to controls (P < .05). CONCLUSION: PPTT proved to be a successful method for treating superficially located HBP carcinomas.
OBJECTIVES: The objective of this study was to assess the short-term effect of plasmonic photothermal therapy (PPTT) on induced hamster buccal pouch (HBP) carcinoma. STUDY DESIGN: Seventy-six Syrian golden male hamsters were used. The induced HBP carcinomas were directly injected with ∼30 nm gold nanospheres followed by 15 min laser exposure (PPTT). RESULTS: PPTT caused rapid growth cessation and dramatic decrease in tumor sizes after 4 weeks of treatment (P < .05) compared to controls. Microscopic and immunohistochemical examination of the tumor biopsies revealed significant differences in the cellular apoptotic index (AI) value and proliferating cell nuclear antigen (PCNA) immunoexpression in PPTT-treated tumor tissue sections compared to controls (P < .05). Survival probability of the treated animals was increased compared to controls (P < .05). CONCLUSION: PPTT proved to be a successful method for treating superficially located HBP carcinomas.
Authors: Radwa A Mehanna; Marwa M Essawy; Mona A Barkat; Ashraf K Awaad; Eman H Thabet; Heba A Hamed; Hagar Elkafrawy; Nehal A Khalil; Abeer Sallam; Marwa A Kholief; Samar S Ibrahim; Ghada M Mourad Journal: World J Stem Cells Date: 2022-01-26 Impact factor: 5.326
Authors: Hend M Abdel Hamid; Zeinab E Darwish; Sahar M Elsheikh; Ghada M Mourad; Hanaa M Donia; Marwa M Afifi Journal: BMC Cancer Date: 2021-02-17 Impact factor: 4.430