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Literature DB >> 23453839

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

Yanming Du¹, Hong Ye, Tina Gill, Lijuan Wang, Fang Guo, Andrea Cuconati, Ju-Tao Guo, Timothy M Block, Jinhong Chang, Xiaodong Xu.

Abstract

Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ containing a terminal tertiary carboxamide moiety was discovered that was a potent inhibitor against BVDV. Further optimization resulted in a structurally more stable lead compound 24 with a submicromolar EC50 against BVDV, Dengue, and Tacaribe; and low cytotoxicity.

Entities: Chemical Disease Species

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Year: 2013 PMID： 23453839 DOI： 10.1016/j.bmcl.2013.01.108

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

Authors: Julia Ma; Shuo Wu; Xuexiang Zhang; Fang Guo; Katherine Yang; Jia Guo; Qing Su; Huagang Lu; Patrick Lam; Yuhuan Li; Zhengyin Yan; William Kinney; Ju-Tao Guo; Timothy M Block; Jinhong Chang; Yanming Du
Journal: ACS Med Chem Lett Date: 2017-01-17 Impact factor: 4.345

2. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

Authors: Xuesen Zhao; Fang Guo; Mary Ann Comunale; Anand Mehta; Mohit Sehgal; Pooja Jain; Andrea Cuconati; Hanxin Lin; Timothy M Block; Jinhong Chang; Ju-Tao Guo
Journal: Antimicrob Agents Chemother Date: 2014-10-27 Impact factor: 5.191

3. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

Authors: Julia Ma; Xuexiang Zhang; Veronica Soloveva; Travis Warren; Fang Guo; Shuo Wu; Huagang Lu; Jia Guo; Qing Su; Helen Shen; Eric Solon; Mary Ann Comunale; Anand Mehta; Ju-Tao Guo; Sina Bavari; Yanming Du; Timothy M Block; Jinhong Chang
Journal: Antiviral Res Date: 2017-12-15 Impact factor: 5.970

4. An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

Authors: Fang Guo; Xuesen Zhao; Tina Gill; Yan Zhou; Matthew Campagna; Lijuan Wang; Fei Liu; Pinghu Zhang; Laura DiPaolo; Yanming Du; Xiaodong Xu; Dong Jiang; Lai Wei; Andrea Cuconati; Timothy M Block; Ju-Tao Guo; Jinhong Chang
Journal: Antiviral Res Date: 2014-04-30 Impact factor: 5.970

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

1. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

2. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

3. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

4. An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

5. Copper-catalyzed intermolecular C(sp³)-H bond functionalization towards the synthesis of tertiary carbamates.

Review 6. Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance.

Review 7. Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

1. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

2. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

3. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

4. An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

5. Copper-catalyzed intermolecular C(sp3)-H bond functionalization towards the synthesis of tertiary carbamates.

Review 6. Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance.

Review 7. Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

5. Copper-catalyzed intermolecular C(sp³)-H bond functionalization towards the synthesis of tertiary carbamates.