OBJECTIVE: The purpose of this study was to directly compare the incidence and magnitude of bacteremia of a 0.12% chlorhexidine pre-procedure rinse to the AHA and the ADA/AAOS recommended 2 g amoxicillin antibiotic prophylaxisduring third molar extractions. STUDY DESIGN: This study was a randomized, blind, placebo-controlled prospective clinical trial involving subjects assigned to a placebo, rinse, or antibiotic group. The incidence and magnitude of bacteremia were analyzed via χ(2) and Kruskal-Wallis/Friedman tests, respectively. RESULTS: There was no statistically significant difference in the incidence and magnitude of bacteremia between the three groups. However, the placebo group apparently resulted in the largest range and highest mean magnitude of bacteremia, followed by the rinse then the antibiotic group. CONCLUSIONS: The results of this novel study may reasonably conclude an oral rinse or systemic antibiotic antimicrobial intervention does not statistically reduce the incidence and magnitude of bacteremia compared to no antimicrobial intervention. Published by Mosby, Inc.
RCT Entities:
OBJECTIVE: The purpose of this study was to directly compare the incidence and magnitude of bacteremia of a 0.12% chlorhexidine pre-procedure rinse to the AHA and the ADA/AAOS recommended 2 g amoxicillin antibiotic prophylaxis during third molar extractions. STUDY DESIGN: This study was a randomized, blind, placebo-controlled prospective clinical trial involving subjects assigned to a placebo, rinse, or antibiotic group. The incidence and magnitude of bacteremia were analyzed via χ(2) and Kruskal-Wallis/Friedman tests, respectively. RESULTS: There was no statistically significant difference in the incidence and magnitude of bacteremia between the three groups. However, the placebo group apparently resulted in the largest range and highest mean magnitude of bacteremia, followed by the rinse then the antibiotic group. CONCLUSIONS: The results of this novel study may reasonably conclude an oral rinse or systemic antibiotic antimicrobial intervention does not statistically reduce the incidence and magnitude of bacteremia compared to no antimicrobial intervention. Published by Mosby, Inc.
Authors: Willem M H Rademacher; Geert H I M Walenkamp; Dirk Jan F Moojen; Johannes G E Hendriks; Theo A Goedendorp; Frederik R Rozema Journal: Acta Orthop Date: 2017-06-22 Impact factor: 3.717
Authors: Effie Edsor; G Agnes Golda Priyadarshini; P Gowri Shankar; V Ramesh Srinivasan; T Vigneswaran; S Pradheep Raja Journal: J Pharm Bioallied Sci Date: 2021-11-10
Authors: Mario Barbosa; Isabel Prada-López; Maximiliano Álvarez; Barbas Amaral; Casares-De-Cal María de los Angeles; Inmaculada Tomás Journal: PLoS One Date: 2015-05-08 Impact factor: 3.240
Authors: Gabriele Cervino; Marco Cicciù; Antonio Biondi; Salvatore Bocchieri; Alan Scott Herford; Luigi Laino; Luca Fiorillo Journal: Antibiotics (Basel) Date: 2019-05-02