PURPOSE: Previous studies have suggested an association between mood and anxiety disorders and peptic ulcer, yet extant work suffers from methodologic limitations. Centrally, previous epidemiologic studies have relied exclusively on self-report of ulcer. This study aimed to investigate the relationship between DSM-IV depression and anxiety disorders and physician-diagnosed ulcer among adults in the general population. METHODS: Data were drawn from a population-based, representative sample of 4181 adults aged 18 to 79 in the German National Health Interview and Examination Survey. RESULTS: Any anxiety disorder (odds ratio [OR], 2.6), panic disorder (OR, 5.2), panic attacks (OR, 3.8), and social phobia (OR, 3.3) were associated with increased likelihood of physician-diagnosed ulcer, compared with those without ulcer. There was evidence of a dose-response relationship between number of mental disorders and likelihood of current ulcer. CONCLUSIONS: These findings provide initial evidence of a link between anxiety disorders and physician-diagnosed ulcer among adults in the community. Future work, ideally taking into account Helicobacter pylori infection, stress, and mental health problems is needed to improve our understanding of the possible mechanisms that can provide insight into the etiology of peptic ulcers.
PURPOSE: Previous studies have suggested an association between mood and anxiety disorders and peptic ulcer, yet extant work suffers from methodologic limitations. Centrally, previous epidemiologic studies have relied exclusively on self-report of ulcer. This study aimed to investigate the relationship between DSM-IV depression and anxiety disorders and physician-diagnosed ulcer among adults in the general population. METHODS: Data were drawn from a population-based, representative sample of 4181 adults aged 18 to 79 in the German National Health Interview and Examination Survey. RESULTS: Any anxiety disorder (odds ratio [OR], 2.6), panic disorder (OR, 5.2), panic attacks (OR, 3.8), and social phobia (OR, 3.3) were associated with increased likelihood of physician-diagnosed ulcer, compared with those without ulcer. There was evidence of a dose-response relationship between number of mental disorders and likelihood of current ulcer. CONCLUSIONS: These findings provide initial evidence of a link between anxiety disorders and physician-diagnosed ulcer among adults in the community. Future work, ideally taking into account Helicobacter pyloriinfection, stress, and mental health problems is needed to improve our understanding of the possible mechanisms that can provide insight into the etiology of peptic ulcers.
Authors: Maria Ines Pinto-Sanchez; Alexander C Ford; Christian A Avila; Elena F Verdu; Stephen M Collins; David Morgan; Paul Moayyedi; Premysl Bercik Journal: Am J Gastroenterol Date: 2015-05-12 Impact factor: 10.864
Authors: Andrea N Niles; Halina J Dour; Annette L Stanton; Peter P Roy-Byrne; Murray B Stein; Greer Sullivan; Cathy D Sherbourne; Raphael D Rose; Michelle G Craske Journal: J Psychosom Res Date: 2014-11-25 Impact factor: 3.006
Authors: Vladeta Ajdacic-Gross; Aleksandra Aleksandrowicz; Stephanie Rodgers; Margot Mutsch; Anja Tesic; Mario Müller; Wolfram Kawohl; Wulf Rössler; Erich Seifritz; Enrique Castelao; Marie-Pierre F Strippoli; Caroline Vandeleur; Roland von Känel; Rosa Paolicelli; Markus A Landolt; Cornelia Witthauer; Roselind Lieb; Martin Preisig Journal: World J Psychiatry Date: 2016-12-22