Literature DB >> 23453247

Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts.

D G Simmons1, J Rakoczy, J Jefferis, R Lourie, H D McIntyre, P A Dawson.   

Abstract

Sulfate is an important nutrient for fetal growth and development. The fetus has no mechanism for producing its own sulfate and is therefore totally reliant on sulfate from the maternal circulation via placental sulfate transport. To build a model of directional sulfate transport in the placenta, we investigated the relative abundance of the 10 known sulfate transporter mRNAs in human placenta from uncomplicated term pregnancies. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. These findings indicate important physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23453247     DOI： 10.1016/j.placenta.2013.01.017

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  11 in total

1.  Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice.

Authors:  Joanna Rakoczy; Zhe Zhang; Francis Gerard Bowling; Paul Anthony Dawson; David Gordon Simmons
Journal:  Cell Res       Date:  2015-08-21       Impact factor: 25.617

2.  Reference intervals for plasma sulfate and urinary sulfate excretion in pregnancy.

Authors:  Paul Anthony Dawson; Scott Petersen; Robyn Rodwell; Phillip Johnson; Kristen Gibbons; Avis McWhinney; Francis Gerard Bowling; Harold David McIntyre
Journal:  BMC Pregnancy Childbirth       Date:  2015-04-17       Impact factor: 3.007

Review 3.  Sulphate in pregnancy.

Authors:  Paul A Dawson; Aoife Elliott; Francis G Bowling
Journal:  Nutrients       Date:  2015-03-04       Impact factor: 5.717

4.  Structure, organization and tissue expression of the pig SLC13A1 and SLC13A4 sulfate transporter genes.

Authors:  Samuel K Barnes; Yvonne A Eiby; Soohyun Lee; Barbara E Lingwood; Paul A Dawson
Journal:  Biochem Biophys Rep       Date:  2017-04-13

5.  Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.

Authors:  Xiao Huang; Pascale Anderle; Lu Hostettler; Marc U Baumann; Daniel V Surbek; Edgar C Ontsouka; Christiane Albrecht
Journal:  BMC Genomics       Date:  2018-03-02       Impact factor: 3.969

6.  Molecular analysis of the human placental cysteine dioxygenase type 1 gene.

Authors:  Paul A Dawson; Shalini J Weerasekera; Ranita J Atcheson; Sarah A Twomey; David G Simmons
Journal:  Mol Genet Metab Rep       Date:  2020-02-06

7.  Cell-specific characterization of the placental methylome.

Authors:  Victor Yuan; Desmond Hui; Yifan Yin; Maria S Peñaherrera; Alexander G Beristain; Wendy P Robinson
Journal:  BMC Genomics       Date:  2021-01-06       Impact factor: 3.969

Review 8.  Physiological and Pathological Functions of SLC26A6.

Authors:  Juan Wang; Wenkang Wang; Hui Wang; Biguang Tuo
Journal:  Front Med (Lausanne)       Date:  2021-01-21

Review 9.  Skeletal Dysplasias Caused by Sulfation Defects.

Authors:  Chiara Paganini; Chiara Gramegna Tota; Andrea Superti-Furga; Antonio Rossi
Journal:  Int J Mol Sci       Date:  2020-04-14       Impact factor: 5.923

10.  Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.

Authors:  Chao Zheng; Xisheng Lin; Xiaolong Xu; Cheng Wang; Jinru Zhou; Bo Gao; Jing Fan; Weiguang Lu; Yaqian Hu; Qiang Jie; Zhuojing Luo; Liu Yang
Journal:  EBioMedicine       Date:  2019-01-23       Impact factor: 8.143
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