Literature DB >> 23452844

By hook or by crook: multifaceted DNA-binding properties of MeCP2.

Jaehoon Shin1, Guo-Li Ming, Hongjun Song.   

Abstract

Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23452844      PMCID： PMC4119793          DOI： 10.1016/j.cell.2013.02.017

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.

Authors:  J D Lewis; R R Meehan; W J Henzel; I Maurer-Fogy; P Jeppesen; F Klein; A Bird
Journal:  Cell       Date:  1992-06-12       Impact factor: 41.582

2.  Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

Authors:  Junjie U Guo; Yijing Su; Chun Zhong; Guo-li Ming; Hongjun Song
Journal:  Cell       Date:  2011-04-14       Impact factor: 41.582

3.  MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.

Authors:  X Nan; F J Campoy; A Bird
Journal:  Cell       Date:  1997-02-21       Impact factor: 41.582

4.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

Authors:  R E Amir; I B Van den Veyver; M Wan; C Q Tran; U Francke; H Y Zoghbi
Journal:  Nat Genet       Date:  1999-10       Impact factor: 38.330

5.  MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

Authors:  Marian Mellén; Pinar Ayata; Scott Dewell; Skirmantas Kriaucionis; Nathaniel Heintz
Journal:  Cell       Date:  2012-12-21       Impact factor: 41.582

Review 6.  The role of MeCP2 in the brain.

Authors:  Jacky Guy; Hélène Cheval; Jim Selfridge; Adrian Bird
Journal:  Annu Rev Cell Dev Biol       Date:  2011-06-29       Impact factor: 13.827

7.  Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Authors:  Xinsheng Nan; Jianghui Hou; Alan Maclean; Jamal Nasir; Maria Jose Lafuente; Xinhua Shu; Skirmantas Kriaucionis; Adrian Bird
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-12       Impact factor: 11.205

8.  Neuronal activity modifies the DNA methylation landscape in the adult brain.

Authors:  Junjie U Guo; Dengke K Ma; Huan Mo; Madeleine P Ball; Mi-Hyeon Jang; Michael A Bonaguidi; Jacob A Balazer; Hugh L Eaves; Bin Xie; Eric Ford; Kun Zhang; Guo-li Ming; Yuan Gao; Hongjun Song
Journal:  Nat Neurosci       Date:  2011-08-28       Impact factor: 24.884

9.  The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.

Authors:  Skirmantas Kriaucionis; Nathaniel Heintz
Journal:  Science       Date:  2009-04-16       Impact factor: 47.728

10.  An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.

Authors:  Steven Andrew Baker; Lin Chen; Angela Dawn Wilkins; Peng Yu; Olivier Lichtarge; Huda Yahya Zoghbi
Journal:  Cell       Date:  2013-02-28       Impact factor: 41.582
  10 in total
  7 in total

Review 1.  DNA methylation and childhood maltreatment: from animal models to human studies.

Authors:  P-E Lutz; G Turecki
Journal:  Neuroscience       Date:  2013-08-08       Impact factor: 3.590

Review 2.  Rett syndrome: a complex disorder with simple roots.

Authors:  Matthew J Lyst; Adrian Bird
Journal:  Nat Rev Genet       Date:  2015-03-03       Impact factor: 53.242

3.  Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.

Authors:  Ke Liu; Chao Xu; Ming Lei; Ally Yang; Peter Loppnau; Timothy R Hughes; Jinrong Min
Journal:  J Biol Chem       Date:  2018-03-22       Impact factor: 5.157

4.  MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1.

Authors:  L Y Zhao; D D Tong; M Xue; H L Ma; S Y Liu; J Yang; Y X Liu; B Guo; L Ni; L Y Liu; Y N Qin; L M Wang; X G Zhao; C Huang
Journal:  Oncogenesis       Date:  2017-07-31       Impact factor: 7.485

5.  MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.

Authors:  Sabine Lagger; John C Connelly; Gabriele Schweikert; Shaun Webb; Jim Selfridge; Bernard H Ramsahoye; Miao Yu; Chuan He; Guido Sanguinetti; Lawrence C Sowers; Malcolm D Walkinshaw; Adrian Bird
Journal:  PLoS Genet       Date:  2017-05-12       Impact factor: 5.917

6.  MeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways.

Authors:  Lingyu Zhao; Yingxun Liu; Dongdong Tong; Yannan Qin; Juan Yang; Meng Xue; Ning Du; Liying Liu; Bo Guo; Ni Hou; Jia Han; Siyuan Liu; Na Liu; Xiaoge Zhao; Lumin Wang; Yanke Chen; Chen Huang
Journal:  EBioMedicine       Date:  2017-01-17       Impact factor: 8.143

7.  MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription.

Authors:  Dan Luo; Wei Ge
Journal:  Cancers (Basel)       Date:  2020-03-23       Impact factor: 6.639
  7 in total

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