BACKGROUND AND PURPOSE: Elevated blood pressure (BP) is associated with the presence of cerebral microbleeds (CMBs) in cross-sectional studies. However, longitudinal studies did not show a convincing relationship. We aimed to determine the association between elevated BP levels and the occurrence of new CMBs after a 2-year follow-up in first-ever lacunar stroke patients using ambulatory BP monitoring. METHODS: Ninety-six first-ever lacunar stroke patients underwent brain MRI and ambulatory BP monitoring at baseline and after 2-year follow-up. We used logistic regression analyses to assess the association of BP levels with new CMBs. RESULTS: We found new CMBs in 17 patients (18%). Higher 24-hour, day and night systolic BP (odds ratio, 2.69; 95% confidence interval, 1.40-5.21 per SD increase for 24-hour BP) and diastolic BP (odds ratio, 2.13; 95% confidence interval, 1.15-3.90 per SD increase for 24-hour BP) at baseline were associated with the development of new CMBs independent of age and sex. BP levels decreased during follow-up in both patients with and without new CMBs. Unlike BP levels at baseline, there was no difference in BP levels at follow-up between patients with and without new CMBs. CONCLUSIONS: Both higher systolic and diastolic BP levels were associated with the development of new CMBs in a population of lacunar stroke patients. Decrease of BP levels during follow-up did not halt progression of CMBs; however, it remains to be determined whether (early) intervention with antihypertensive drugs can slow down progression of CMBs.
BACKGROUND AND PURPOSE: Elevated blood pressure (BP) is associated with the presence of cerebral microbleeds (CMBs) in cross-sectional studies. However, longitudinal studies did not show a convincing relationship. We aimed to determine the association between elevated BP levels and the occurrence of new CMBs after a 2-year follow-up in first-ever lacunar strokepatients using ambulatory BP monitoring. METHODS: Ninety-six first-ever lacunar strokepatients underwent brain MRI and ambulatory BP monitoring at baseline and after 2-year follow-up. We used logistic regression analyses to assess the association of BP levels with new CMBs. RESULTS: We found new CMBs in 17 patients (18%). Higher 24-hour, day and night systolic BP (odds ratio, 2.69; 95% confidence interval, 1.40-5.21 per SD increase for 24-hour BP) and diastolic BP (odds ratio, 2.13; 95% confidence interval, 1.15-3.90 per SD increase for 24-hour BP) at baseline were associated with the development of new CMBs independent of age and sex. BP levels decreased during follow-up in both patients with and without new CMBs. Unlike BP levels at baseline, there was no difference in BP levels at follow-up between patients with and without new CMBs. CONCLUSIONS: Both higher systolic and diastolic BP levels were associated with the development of new CMBs in a population of lacunar strokepatients. Decrease of BP levels during follow-up did not halt progression of CMBs; however, it remains to be determined whether (early) intervention with antihypertensive drugs can slow down progression of CMBs.
Authors: Ashkan Shoamanesh; Lesly A Pearce; Carlos Bazan; Luciana Catanese; Leslie A McClure; Mukul Sharma; Joan Marti-Fabregas; David C Anderson; Carlos S Kase; Robert G Hart; Oscar R Benavente Journal: Ann Neurol Date: 2017-07-19 Impact factor: 10.422
Authors: Jessica C Foster-Dingley; Justine E F Moonen; Anne A van den Berg-Huijsmans; Anton J M de Craen; Wouter de Ruijter; Jeroen van der Grond; Roos C van der Mast Journal: J Clin Hypertens (Greenwich) Date: 2015-04-13 Impact factor: 3.738
Authors: Esther M C van Leijsen; Ingeborg W M van Uden; Mohsen Ghafoorian; Mayra I Bergkamp; Valerie Lohner; Eline C M Kooijmans; Helena M van der Holst; Anil M Tuladhar; David G Norris; Ewoud J van Dijk; Loes C A Rutten-Jacobs; Bram Platel; Catharina J M Klijn; Frank-Erik de Leeuw Journal: Neurology Date: 2017-09-06 Impact factor: 9.910
Authors: Zhong-Song Shi; Gary R Duckwiler; Reza Jahan; Satoshi Tateshima; Nestor R Gonzalez; Viktor Szeder; Jeffrey L Saver; Doojin Kim; Latisha K Ali; Sidney Starkman; Paul M Vespa; Noriko Salamon; J Pablo Villablanca; Fernando Viñuela; Lei Feng; Yince Loh; David S Liebeskind Journal: Medicine (Baltimore) Date: 2015-11 Impact factor: 1.817