Carolina Garcia-Vidal1, Diego Viasus, Jordi Carratalà. 1. Infectious Disease Service, Hospital Universitari de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. carolgv75@hotmail.com
Abstract
PURPOSE OF REVIEW: Invasive fungal infection (IFI) is increasingly being recognized as a significant cause of morbidity and mortality in immunosuppressed patients. This review focuses on the latest literature reports concerning the pathogenesis of IFI in this population. RECENT FINDINGS: New virulence factors of Candida and Aspergillus have recently been identified. The past few months have brought significant advances in our understanding of how the immune system acts against fungal infection, especially with regard to the role of mucosa in the innate immune system, the arsenal of innate immune recognition receptors and the pathways connecting innate and adaptive immunity. SUMMARY: Knowledge of fungal pathogenesis and host immune response can help to optimize the management of fungal infections. Greater understanding of these processes may aid physicians in developing better prophylactic measures and antifungal or immunomodulatory therapies.
PURPOSE OF REVIEW: Invasive fungal infection (IFI) is increasingly being recognized as a significant cause of morbidity and mortality in immunosuppressed patients. This review focuses on the latest literature reports concerning the pathogenesis of IFI in this population. RECENT FINDINGS: New virulence factors of Candida and Aspergillus have recently been identified. The past few months have brought significant advances in our understanding of how the immune system acts against fungal infection, especially with regard to the role of mucosa in the innate immune system, the arsenal of innate immune recognition receptors and the pathways connecting innate and adaptive immunity. SUMMARY: Knowledge of fungal pathogenesis and host immune response can help to optimize the management of fungal infections. Greater understanding of these processes may aid physicians in developing better prophylactic measures and antifungal or immunomodulatory therapies.
Authors: Norio Takeshita; Minoas Evangelinos; Lu Zhou; Tomoko Serizawa; Rosa A Somera-Fajardo; Ling Lu; Naoki Takaya; G Ulrich Nienhaus; Reinhard Fischer Journal: Proc Natl Acad Sci U S A Date: 2017-05-15 Impact factor: 11.205
Authors: Nikolaus Rieber; Roel P Gazendam; Alexandra F Freeman; Amy P Hsu; Amanda L Collar; Janyce A Sugui; Rebecca A Drummond; Chokechai Rongkavilit; Kevin Hoffman; Carolyn Henderson; Lily Clark; Markus Mezger; Muthulekha Swamydas; Maik Engeholm; Rebecca Schüle; Bettina Neumayer; Frank Ebel; Constantinos M Mikelis; Stefania Pittaluga; Vinod K Prasad; Anurag Singh; Joshua D Milner; Kelli W Williams; Jean K Lim; Kyung J Kwon-Chung; Steven M Holland; Dominik Hartl; Taco W Kuijpers; Michail S Lionakis Journal: JCI Insight Date: 2016-10-20
Authors: Melisa M Shah; Eric I Hsiao; Carl M Kirsch; Amit Gohil; Supriya Narasimhan; David A Stevens Journal: Diagn Microbiol Infect Dis Date: 2018-02-02 Impact factor: 2.803