OBJECTIVE: In order to conclude on the megakaryopoietic activity during thrombocytopenia in sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF). STUDY DESIGN: Serial measurements of platelet counts and IPF in neonates with blood culture-proven late-onset sepsis (n=21) or surgical NEC (n=12) at T0: prior to the diagnosis of sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset. RESULT: In parallel to declining platelet counts, the median absolute IPF significantly decreased between T0 and T2 in neonates with sepsis or NEC. We found a significant positive correlation between the platelet count and absolute IPF (r=0.71; P<0.001). In patients with low IPF (<2 per nl), the platelet count did not subsequently increase. Neonates with NEC who died exhibited significantly lower IPF compared with survivors (P<0.05). CONCLUSION: Low absolute IPF values during the course of neonatal sepsis/NEC suggest suppression of megakaryopoietic activity.
OBJECTIVE: In order to conclude on the megakaryopoietic activity during thrombocytopenia in sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF). STUDY DESIGN: Serial measurements of platelet counts and IPF in neonates with blood culture-proven late-onset sepsis (n=21) or surgical NEC (n=12) at T0: prior to the diagnosis of sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset. RESULT: In parallel to declining platelet counts, the median absolute IPF significantly decreased between T0 and T2 in neonates with sepsis or NEC. We found a significant positive correlation between the platelet count and absolute IPF (r=0.71; P<0.001). In patients with low IPF (<2 per nl), the platelet count did not subsequently increase. Neonates with NEC who died exhibited significantly lower IPF compared with survivors (P<0.05). CONCLUSION: Low absolute IPF values during the course of neonatal sepsis/NEC suggest suppression of megakaryopoietic activity.
Authors: Sarah J Higgins; Karen De Ceunynck; John A Kellum; Xiuying Chen; Xuesong Gu; Sharjeel A Chaudhry; Sol Schulman; Towia A Libermann; Shulin Lu; Nathan I Shapiro; David C Christiani; Robert Flaumenhaft; Samir M Parikh Journal: J Clin Invest Date: 2018-03-05 Impact factor: 14.808
Authors: B C MacQueen; R D Christensen; E Henry; A M Romrell; T J Pysher; S T Bennett; M C Sola-Visner Journal: J Perinatol Date: 2017-04-06 Impact factor: 2.521
Authors: Hannes Sallmon; Andreas Weimann; Christoph Bührer; Boris Metze; Christof Dame; Malte Cremer Journal: Front Pediatr Date: 2021-06-25 Impact factor: 3.418