Literature DB >> 23448701

Synthesis of 3-cyanoindole derivatives mediated by copper(I) iodide using benzyl cyanide.

On Ying Yuen1, Pui Ying Choy, Wing Kin Chow, Wing Tak Wong, Fuk Yee Kwong.   

Abstract

Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.

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Year:  2013        PMID： 23448701     DOI： 10.1021/jo3028278

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors.

Authors:  Letizia Crocetti; Igor A Schepetkin; Giovanna Ciciani; Maria Paola Giovannoni; Gabriella Guerrini; Antonella Iacovone; Andrei I Khlebnikov; Liliya N Kirpotina; Mark T Quinn; Claudia Vergelli
Journal:  Drug Dev Res       Date:  2016-07-30       Impact factor: 4.360

2.  Copper-catalyzed aerobic radical C-C bond cleavage of N-H ketimines.

Authors:  Ya Lin Tnay; Gim Yean Ang; Shunsuke Chiba
Journal:  Beilstein J Org Chem       Date:  2015-10-19       Impact factor: 2.883
  2 in total

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