AIMS/HYPOTHESIS: Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults. METHODS: Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods. RESULTS: Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached. CONCLUSION/ INTERPRETATION: Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.
AIMS/HYPOTHESIS: Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults. METHODS: Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods. RESULTS: Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached. CONCLUSION/ INTERPRETATION: Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.
Entities:
Keywords:
Type 1 diabetes; epidemiology; farm; hygiene hypothesis; living environment; microbial deprivation
Authors: Noora Nurminen; Damiano Cerrone; Jussi Lehtonen; Anirudra Parajuli; Marja Roslund; Maria Lönnrot; Jorma Ilonen; Jorma Toppari; Riitta Veijola; Mikael Knip; Juho Rajaniemi; Olli H Laitinen; Aki Sinkkonen; Heikki Hyöty Journal: Diabetes Care Date: 2021-05-05 Impact factor: 19.112
Authors: Laura Sgrazzutti; Francesco Sansone; Marina Attanasi; Sabrina Di Pillo; Francesco Chiarelli Journal: Int J Mol Sci Date: 2021-05-28 Impact factor: 5.923