OBJECTIVES: To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal occlusion (FETO) and compare it with historical controls with less severe forms of CDH that were managed expectantly. METHODS: This was a prospective, multicenter study on neonatal outcomes and prenatal predictors in 90 FETO survivors (78 left-sided, 12 right) and 41 controls from the antenatal CDH registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including the need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension. RESULTS: Gestational age at delivery was predictive of duration of assisted ventilation (P = 0.046), days on supplemental oxygen (P = 0.019) and age at full enteral feeding (P = 0.020). When delivery took place after 34 weeks' gestation, neonatal morbidity of FETO cases was comparable with that of expectantly managed cases with moderate hypoplasia. CONCLUSIONS: Fetal intervention for severe CDH is associated with neonatal morbidity that is comparable with that of an expectantly managed group with less severe disease.
OBJECTIVES: To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal occlusion (FETO) and compare it with historical controls with less severe forms of CDH that were managed expectantly. METHODS: This was a prospective, multicenter study on neonatal outcomes and prenatal predictors in 90 FETO survivors (78 left-sided, 12 right) and 41 controls from the antenatal CDH registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including the need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension. RESULTS: Gestational age at delivery was predictive of duration of assisted ventilation (P = 0.046), days on supplemental oxygen (P = 0.019) and age at full enteral feeding (P = 0.020). When delivery took place after 34 weeks' gestation, neonatal morbidity of FETO cases was comparable with that of expectantly managed cases with moderate hypoplasia. CONCLUSIONS: Fetal intervention for severe CDH is associated with neonatal morbidity that is comparable with that of an expectantly managed group with less severe disease.
Authors: Augusto Zani; Wendy K Chung; Jan Deprest; Matthew T Harting; Tim Jancelewicz; Shaun M Kunisaki; Neil Patel; Lina Antounians; Pramod S Puligandla; Richard Keijzer Journal: Nat Rev Dis Primers Date: 2022-06-01 Impact factor: 52.329
Authors: Abigail Wilpers; Anna Y Lynn; Barbara Eichhorn; Amy B Powne; Megan Lagueux; Janene Batten; Mert Ozan Bahtiyar; Cary P Gross Journal: Fetal Diagn Ther Date: 2022-03-10 Impact factor: 2.208
Authors: Francesca Maria Russo; Alexandra Benachi; Tim Van Mieghem; Jan De Hoon; Kristel Van Calsteren; Pieter Annaert; Jean-Marc Tréluyer; Karel Allegaert; Jan Deprest Journal: Trials Date: 2018-09-27 Impact factor: 2.279
Authors: Jan A Deprest; Kypros H Nicolaides; Alexandra Benachi; Eduard Gratacos; Greg Ryan; Nicola Persico; Haruhiko Sago; Anthony Johnson; Mirosław Wielgoś; Christoph Berg; Ben Van Calster; Francesca M Russo Journal: N Engl J Med Date: 2021-06-08 Impact factor: 176.079
Authors: D Basurto; N Sananès; T Bleeser; I Valenzuela; N De Leon; L Joyeux; E Verbeken; S Vergote; L Van der Veeken; F M Russo; J Deprest Journal: Ultrasound Obstet Gynecol Date: 2021-01 Impact factor: 8.678
Authors: Lennart Van der Veeken; Francesca Maria Russo; Luc De Catte; Eduard Gratacos; Alexandra Benachi; Yves Ville; Kypros Nicolaides; Christoph Berg; Glenn Gardener; Nicola Persico; Pietro Bagolan; Greg Ryan; Michael A Belfort; Jan Deprest Journal: Gynecol Surg Date: 2018-05-08