Literature DB >> 23443605

Transvaginal sono-guided aspiration of gestational sac concurrent with a local methotrexate injection for the treatment of unruptured cesarean scar pregnancy.

Kok-Min Seow1, Peng-Hui Wang, Lee-Wen Huang, Jiann-Loung Hwang.   

Abstract

PURPOSE: Cesarean scar pregnancy (CSP) is one of the rarest forms of ectopic pregnancy. A delay in treatment can lead to massive bleeding, uterine rupture, and life-threatening maternal morbidity. We present a conservative method for the management of CSP at a single tertiary centre over a 6-year period.
METHODS: Eleven patients with unruptured CSPs who were treated by transvaginal aspiration of the gestational sac followed by a local methotrexate injection were evaluated.
RESULTS: Gestational age at diagnosis ranged from 5 + 2 weeks to 7 + 4 weeks. Seven of the patients had undergone two prior Caesarean sections (63.6 %). The levels of β-hCG at the time of diagnosis ranged from 1,290 to 81,586 mIu/ml. The mean time of the procedure was 8.2 ± 1.6 min. During follow up, 54.5 % of the patients may need an additional systemic MTX injection due to an elevation of β-hCG. Estimated blood loss of the procedure was <50 ml and no blood transfusion is needed. This method has a shorter operative time, less blood loss and no hospitalization is needed for CSPs. All patients had their uterus successfully preserved without maternal morbidity or mortality.
CONCLUSIONS: Transvaginal sono-guided sac aspiration concurrent with a local MTX injection is an effective management option for preserving the fertility of women with an unruptured CSP. However, additional systemic MTX injection may be needed if β-hCG levels >20,000 mIU/ml at diagnosis.

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Year:  2013        PMID: 23443605     DOI: 10.1007/s00404-013-2765-4

Source DB:  PubMed          Journal:  Arch Gynecol Obstet        ISSN: 0932-0067            Impact factor:   2.344


  8 in total

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2.  Analysis of risk factors for intraoperative hemorrhage of cesarean scar pregnancy.

Authors:  Yan Ma; Minfang Shao; Xiaonan Shao
Journal:  Medicine (Baltimore)       Date:  2017-06       Impact factor: 1.889

3.  Evaluation of clinical effect of transabdominal sonography and transvaginal sonography in early diagnosis of ectopic gestation.

Authors:  Yinghui Li; Tao Feng; Jiandong Sun
Journal:  Pak J Med Sci       Date:  2017 Jan-Feb       Impact factor: 1.088

4.  Successful Treatment of Caesarean Scar Pregnancies by Local Treatment Only.

Authors:  Shinji Tanigaki; Chie Nagata; Kazunori Ueno; Nobuaki Ozawa; Shinichi Nagaoka; Kei Tanaka; Haruhiko Sago; Mitsutoshi Iwashita
Journal:  Obstet Gynecol Int       Date:  2017-03-15

5.  Risk Factor for Residue After Uterine Artery Chemotherapy and Embolization in Combination with Dilatation and Curettage for Treating Caesarean Scar Pregnancy.

Authors:  Feng Cheng; Dan Shan; Sijia Guo; Shuang Cheng; Hongwei Yang; Jialin Han; Tongxiu Hu
Journal:  Curr Mol Med       Date:  2019       Impact factor: 2.222

6.  Evaluation of treatment of previous cesarean scar pregnancy with methotrexate: a systematic review and meta-analysis.

Authors:  Nader Salari; Mohsen Kazeminia; Shamarina Shohaimi; Anis Al-Dawlah Nankali; Masoud Mohammadi
Journal:  Reprod Biol Endocrinol       Date:  2020-11-09       Impact factor: 5.211

7.  Successful Management of Caesarean Scar Ectopic Pregnancies: A Report of Five Cases.

Authors:  Neena Malhotra; Nilofar Noor; Piyush Bansal; K Aparna Sharma
Journal:  J Reprod Infertil       Date:  2021 Jul-Sep

8.  Ultrasound-guided local injection of methotrexate and systemic intramuscular methotrexate in the treatment of cesarean scar pregnancy.

Authors:  Young Ran Kim; Myoung Jin Moon
Journal:  Obstet Gynecol Sci       Date:  2017-12-12
  8 in total

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