Literature DB >> 23441617

Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line.

Muhammad Aliyu1, Oyeronke A Odunola, Ahsana D Farooq, Huma Rasheed, Ahmed M Mesaik, Muhammad I Choudhary, Iffat S Channa, Salman A Khan, Ochuko L Erukainure.   

Abstract

Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

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Year:  2013        PMID： 23441617     DOI： 10.1080/01635581.2013.756920

Source DB:  PubMed          Journal:  Nutr Cancer        ISSN： 0163-5581            Impact factor:   2.900


  10 in total

Review 1.  Uses of Natural Honey in Cancer: An Updated Review.

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2.  Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats.

Authors:  Aliyu Muhammad; Oyeronke A Odunola; Michael A Gbadegesin; Abdullahi B Sallau; Uche S Ndidi; Mohammed A Ibrahim
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Review 3.  Honey and Health: A Review of Recent Clinical Research.

Authors:  Saeed Samarghandian; Tahereh Farkhondeh; Fariborz Samini
Journal:  Pharmacognosy Res       Date:  2017 Apr-Jun

Review 4.  Honey as a Complementary Medicine.

Authors:  M G Miguel; M D Antunes; M L Faleiro
Journal:  Integr Med Insights       Date:  2017-04-24

Review 5.  The Immunomodulatory Effects of Honey and Associated Flavonoids in Cancer.

Authors:  Razan J Masad; Shoja M Haneefa; Yassir A Mohamed; Ashraf Al-Sbiei; Ghada Bashir; Maria J Fernandez-Cabezudo; Basel K Al-Ramadi
Journal:  Nutrients       Date:  2021-04-13       Impact factor: 5.717

6.  Chemical Composition and the Anticancer, Antimicrobial, and Antioxidant Properties of Acacia Honey from the Hail Region: The in vitro and in silico Investigation.

Authors:  Walid Sabri Hamadou; Nouha Bouali; Riadh Badraoui; Ramzi Hadj Lajimi; Assia Hamdi; Mousa Alreshidi; Mitesh Patel; Mohd Adnan; Arif Jamal Siddiqui; Emira Noumi; Visweswara Rao Pasupuleti; Mejdi Snoussi
Journal:  Evid Based Complement Alternat Med       Date:  2022-08-04       Impact factor: 2.650

7.  Flowers of Clerodendrum volubile modulates redox homeostasis and suppresses DNA fragmentation in Fe2+ - induced oxidative hepatic and pancreatic injuries; and inhibits carbohydrate catabolic enzymes linked to type 2 diabetes.

Authors:  Ochuko L Erukainure; Olajumoke A Oyebode; Veronica F Salau; Neil A Koorbanally; Md Shahidul Islam
Journal:  J Diabetes Metab Disord       Date:  2019-11-18

8.  Ameliorative Effects of Acacia Honey against Sodium Arsenite-Induced Oxidative Stress in Some Viscera of Male Wistar Albino Rats.

Authors:  Muhammad Aliyu; Sani Ibrahim; Hajiya M Inuwa; Abdullahi B Sallau; Olagunju Abbas; Idowu A Aimola; Nathan Habila; Ndidi S Uche
Journal:  Biochem Res Int       Date:  2013-12-03

9.  Fatty Acids Rich Extract From Clerodendrum volubile Suppresses Cell Migration; Abates Oxidative Stress; and Regulates Cell Cycle Progression in Glioblastoma Multiforme (U87 MG) Cells.

Authors:  Ochuko L Erukainure; Nadia Ashraf; Asma S Naqvi; Moses Z Zaruwa; Aliyu Muhammad; Adenike D Odusote; Gloria N Elemo
Journal:  Front Pharmacol       Date:  2018-03-20       Impact factor: 5.810

Review 10.  Phenolic Compounds in Honey and Their Associated Health Benefits: A Review.

Authors:  Danila Cianciosi; Tamara Yuliett Forbes-Hernández; Sadia Afrin; Massimiliano Gasparrini; Patricia Reboredo-Rodriguez; Piera Pia Manna; Jiaojiao Zhang; Leire Bravo Lamas; Susana Martínez Flórez; Pablo Agudo Toyos; José Luis Quiles; Francesca Giampieri; Maurizio Battino
Journal:  Molecules       Date:  2018-09-11       Impact factor: 4.411
  10 in total

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