PURPOSE: To prospectively compare calf muscle BOLD MRI with transcutaneous oxygen pressure (TcPO2 ) measurement in patients with systemic sclerosis (SSc) and healthy volunteers and thereby get insight into the pathogenesis of vasculopathy in this connective tissue disorder. MATERIALS AND METHODS: Twelve patients with SSc (6 women and 6 men, mean age 53.5 ± 10.0 years) and 12 healthy volunteers (4 men and 8 women, mean age 47 ± 12.1 years) were examined using muscle BOLD MRI and TcPO2. A cuff compression at mid-thigh level was performed to provoke ischemia and reactive hyperemia. BOLD measurements were acquired on a 3 Tesla whole body-scanner in the upper calf region using a multi-echo EPI-sequence with four echo-times (TE: 9/20/31/42 ms) and a repetition time of 2 s. Empirical cross-correlation analysis depending on time lags between BOLD- and TcPO2-measurements was performed. RESULTS: Maximal cross-correlation of BOLD T2*- and TcPO2-measurements was calculated as 0.93 (healthy volunteers) and 0.90 (SSc patients) for a time lag of approximately 40 s. Both modalities showed substantial differences regarding time course parameters between the SSc patients and healthy volunteers. CONCLUSION: Skeletal muscle BOLD MRI correlated very well with TcPO2 . T2* changes seem to reflect reoxygenation deficits in deeper muscle tissue of SSc patients.
PURPOSE: To prospectively compare calf muscle BOLD MRI with transcutaneous oxygen pressure (TcPO2 ) measurement in patients with systemic sclerosis (SSc) and healthy volunteers and thereby get insight into the pathogenesis of vasculopathy in this connective tissue disorder. MATERIALS AND METHODS: Twelve patients with SSc (6 women and 6 men, mean age 53.5 ± 10.0 years) and 12 healthy volunteers (4 men and 8 women, mean age 47 ± 12.1 years) were examined using muscle BOLD MRI and TcPO2. A cuff compression at mid-thigh level was performed to provoke ischemia and reactive hyperemia. BOLD measurements were acquired on a 3 Tesla whole body-scanner in the upper calf region using a multi-echo EPI-sequence with four echo-times (TE: 9/20/31/42 ms) and a repetition time of 2 s. Empirical cross-correlation analysis depending on time lags between BOLD- and TcPO2-measurements was performed. RESULTS: Maximal cross-correlation of BOLD T2*- and TcPO2-measurements was calculated as 0.93 (healthy volunteers) and 0.90 (SSc patients) for a time lag of approximately 40 s. Both modalities showed substantial differences regarding time course parameters between the SSc patients and healthy volunteers. CONCLUSION: Skeletal muscle BOLD MRI correlated very well with TcPO2 . T2* changes seem to reflect reoxygenation deficits in deeper muscle tissue of SSc patients.
Authors: Jessica E Caterini; Alyaa H Elzibak; Emilie Jean St Michel; Brian W McCrindle; Andrew N Redington; Sara Thompson; Michael D Noseworthy; Greg D Wells Journal: MAGMA Date: 2014-09-24 Impact factor: 2.310
Authors: Markus Aschwanden; Sasan Partovi; Bjoern Jacobi; Nathan Fergus; Anja-Carina Schulte; Mark R Robbin; Deniz Bilecen; Daniel Staub Journal: Cardiovasc Diagn Ther Date: 2014-04
Authors: Mitchel R Stacy; Christopher M Caracciolo; Maolin Qiu; Prasanta Pal; Tyler Varga; Robert Todd Constable; Albert J Sinusas Journal: Physiol Rep Date: 2016-08
Authors: Sarah L West; Clodagh S O'Gorman; Alyaa H Elzibak; Jessica Caterini; Michael D Noseworthy; Tammy Rayner; Jill Hamilton; Greg D Wells Journal: BBA Clin Date: 2014-12-09
Authors: Martina Gurgitano; Giulia Signorelli; Giovanni Maria Rodà; Alessandro Liguori; Marco Pandolfi; Giuseppe Granata; Antonio Arrichiello; Anna Maria Ierardi; Aldo Paolucci; Gianpaolo Carrafiello Journal: Acta Biomed Date: 2020-09-23